Intervention
Metformin
- Works
- 349
- Clinical trials
- 6
- Total citations
- 31,955
- Open access
- 312
Evidence brief
previewSynthesis (preview — no live AI key for the active provider):
Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].
Publication velocity
20022026
Clinical trials
Vitality in Aging Research Group, Inc. 2022
Open access · US-GOV
Pilot Study to Test the Safety and Efficacy of Metformin, Dasatinib, Rapamycin and Nutritional Supplements (Bio-quercetin; Bio-fisetin; Glucosamine; Nicotinamide Riboside; Trans-resveratrol) in Reducing Clinical Measures of Aging in Older Adults
VA Office of Research and Development 2021
Open access · US-GOV
Lifestyle Intervention Plus Metformin to Treat Frailty in Older Veterans With Obesity
Oklahoma Medical Research Foundation 2020
Open access · US-GOV
Does Insulin Sensitivity Impact the Potential of Metformin to Slow Aging
University of Utah 2019
Open access · US-GOV
Metformin to Prevent Inactivity-induced Loss of Muscle Health During Aging
The University of Texas Health Science Center at San Antonio 2019
Open access · US-GOV
Metformin and Vaccine Response in Older Adults
Mayo Clinic 2018
Open access · US-GOV
(MATE) Metformin and Aging Trial in the Elderly: A Pilot and Feasibility Study
Most-cited works
Diabetologia 2017
Open access · CC-BY
The mechanisms of action of metformin
Nature 2015
Preprint · OA
Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota
Cochrane Database of Systematic Reviews 2009
Open access · OA
Interventions for treating obesity in children
Nature Communications 2013
Open access · OA
Metformin improves healthspan and lifespan in mice
Aging 2017
Open access · CC-BY
Epigenetic clock analysis of diet, exercise, education, and lifestyle factors
Circulation Research 2016
Open access · CC-BY
Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status
PLoS ONE 2010
Open access · CC-BY
Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1
Nature Reviews Endocrinology 2023
Open access · OA
Metformin: update on mechanisms of action and repurposing potential
Diabetes 2006
Open access · CC-BY
Polyphenols Stimulate AMP-Activated Protein Kinase, Lower Lipids, and Inhibit Accelerated Atherosclerosis in Diabetic LDL Receptor–Deficient Mice
Cell Metabolism 2020
Open access · OA