Intervention
Metformin
- Works
- 40
- Clinical trials
- 4
- Total citations
- 4,038
- Open access
- 35
Evidence brief
previewSynthesis (preview — no live AI key for the active provider):
Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].
Publication velocity
20102026
Clinical trials
Vitality in Aging Research Group, Inc. 2022
Open access · US-GOV
Pilot Study to Test the Safety and Efficacy of Metformin, Dasatinib, Rapamycin and Nutritional Supplements (Bio-quercetin; Bio-fisetin; Glucosamine; Nicotinamide Riboside; Trans-resveratrol) in Reducing Clinical Measures of Aging in Older Adults
VA Office of Research and Development 2021
Open access · US-GOV
Lifestyle Intervention Plus Metformin to Treat Frailty in Older Veterans With Obesity
University of Utah 2019
Open access · US-GOV
Metformin to Prevent Inactivity-induced Loss of Muscle Health During Aging
The University of Texas Health Science Center at San Antonio 2019
Open access · US-GOV
Metformin and Vaccine Response in Older Adults
Most-cited works
Nature Communications 2013
Open access · OA
Metformin improves healthspan and lifespan in mice
PLoS ONE 2010
Open access · CC-BY
Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1
Frontiers in Endocrinology 2018
Open access · CC-BY
The Therapeutic Potential of Metformin in Neurodegenerative Diseases
Frontiers in Endocrinology 2021
Open access · CC-BY
A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan
Clinical Cancer Research 2010
Open access · OA
Metformin: A Therapeutic Opportunity in Breast Cancer
Journal of Translational Medicine 2023
Open access · CC-BY
Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing
Diabetes Obesity and Metabolism 2018
Preprint · OA
Epigenetic effects of metformin: From molecular mechanisms to clinical implications
Theranostics 2022
Open access · CC-BY
Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms
Oncotarget 2016
Open access · CC-BY
Anti-tumor activity of metformin: from metabolic and epigenetic perspectives
Journal of Experimental & Clinical Cancer Research 2019
Open access · CC-BY