Intervention
Rapamycin / mTOR inhibition
- Works
- 99
- Clinical trials
- 5
- Total citations
- 24,732
- Open access
- 96
Evidence brief
previewSynthesis (preview — no live AI key for the active provider):
Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].
Publication velocity
20042026
Clinical trials
Icahn School of Medicine at Mount Sinai 2025
Open access · US-GOV
A Phase 1b, Multi-cohort Clinical Trial Assessing Safety and Feasibility of Exercise and Spermidine Administered in Conjunction With Lamivudine (RTi) or Rapamycin (mTORi) to Assess Impact on Dynamic Changes of Inflammation and Aging
Odense University Hospital 2024
Open access · US-GOV
Targeting mTOR With Everolimus and/or Physical Training for Preventing Postmenopausal Bone Loss and Accelerated Skeletal Aging: The RapaLoad Study
Columbia University 2023
Open access · US-GOV
Effect of Rapamycin in Ovarian Aging
Vitality in Aging Research Group, Inc. 2022
Open access · US-GOV
Pilot Study to Test the Safety and Efficacy of Metformin, Dasatinib, Rapamycin and Nutritional Supplements (Bio-quercetin; Bio-fisetin; Glucosamine; Nicotinamide Riboside; Trans-resveratrol) in Reducing Clinical Measures of Aging in Older Adults
Mayo Clinic 2012
Open access · US-GOV
Role of Exercise and Low-Dose Rapamycin on Age-Associated Impairments in Older Adults With Coronary Artery Disease: Cardiac Rehabilitation And Rapamycin in Elderly (CARE) Trial
Most-cited works
Cellular Physiology and Biochemistry 2017
Open access · CC-BY
Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy
Genes & Development 2004
Open access · OA
Upstream and downstream of mTOR
Genes & Development 2009
Open access · OA
Autophagy mediates the mitotic senescence transition
Frontiers in Oncology 2022
Open access · CC-BY
PI3K/Akt/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway?
Current Drug Targets 2011
Open access · OA
The Targets of Curcumin
Translational Neurodegeneration 2017
Open access · CC-BY
Protein misfolding in neurodegenerative diseases: implications and strategies
Circulation Research 2018
Open access · OA
Mechanisms of Dysfunction in the Aging Vasculature and Role in Age-Related Disease
Gerontology 2017
Preprint · OA
mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review
International Journal of Molecular Sciences 2020
Open access · CC-BY
The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling
Oncotarget 2014
Open access · CC-BY