Intervention
Rapamycin / mTOR inhibition
- Works
- 718
- Clinical trials
- 5
- Total citations
- 96,159
- Open access
- 662
Evidence brief
previewSynthesis (preview — no live AI key for the active provider):
Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].
Publication velocity
19832026
Clinical trials
Icahn School of Medicine at Mount Sinai 2025
Open access · US-GOV
A Phase 1b, Multi-cohort Clinical Trial Assessing Safety and Feasibility of Exercise and Spermidine Administered in Conjunction With Lamivudine (RTi) or Rapamycin (mTORi) to Assess Impact on Dynamic Changes of Inflammation and Aging
Odense University Hospital 2024
Open access · US-GOV
Targeting mTOR With Everolimus and/or Physical Training for Preventing Postmenopausal Bone Loss and Accelerated Skeletal Aging: The RapaLoad Study
Columbia University 2023
Open access · US-GOV
Effect of Rapamycin in Ovarian Aging
Vitality in Aging Research Group, Inc. 2022
Open access · US-GOV
Pilot Study to Test the Safety and Efficacy of Metformin, Dasatinib, Rapamycin and Nutritional Supplements (Bio-quercetin; Bio-fisetin; Glucosamine; Nicotinamide Riboside; Trans-resveratrol) in Reducing Clinical Measures of Aging in Older Adults
Mayo Clinic 2012
Open access · US-GOV
Role of Exercise and Low-Dose Rapamycin on Age-Associated Impairments in Older Adults With Coronary Artery Disease: Cardiac Rehabilitation And Rapamycin in Elderly (CARE) Trial
Most-cited works
Cellular Physiology and Biochemistry 2017
Open access · CC-BY
Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy
Genes & Development 2004
Preprint · OA
Upstream and downstream of mTOR
Nature 2009
Preprint · OA
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Molecular Cancer 2023
Open access · CC-BY
PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
Signal Transduction and Targeted Therapy 2020
Open access · CC-BY
Targeting cancer stem cell pathways for cancer therapy
Cell Metabolism 2010
Open access · CC-BY
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
Journal of Clinical Investigation 2013
Open access · OA
The role of mitochondria in aging
Genes & Development 2009
Open access · OA
Autophagy mediates the mitotic senescence transition
PLoS ONE 2010
Open access · CC-BY
Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease
Genes & Development 2006
Preprint · OA