Model organism
Drosophila
- Works
- 1,114
- Most cited
- 3,134
Most-cited works
Oxidative Stress, Caloric Restriction, and Aging
Under normal physiological conditions, the use of oxygen by cells of aerobic organisms generates potentially deleterious reactive oxygen metabolites. A chronic state of oxidative stress exists in cells because of an imbalance between prooxi...
PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
Loss-of-function mutations in PINK1 and Parkin cause parkinsonism in humans and mitochondrial dysfunction in model organisms. Parkin is selectively recruited from the cytosol to damaged mitochondria to trigger their autophagy. How Parkin re...
Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it...
Small molecule drug screening in Drosophila identifies the 5HT2A receptor as a feeding modulation target
Dysregulation of eating behavior can lead to obesity, which affects 10% of the adult population worldwide and accounts for nearly 3 million deaths every year. Despite this burden on society, we currently lack effective pharmacological treat...
Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway
This 2004 study in Current Biology examines how the modulation of genes within the TOR signaling pathway affects the lifespan of Drosophila.
The Bacterial Symbiont Wolbachia Induces Resistance to RNA Viral Infections in Drosophila melanogaster
Wolbachia are vertically transmitted, obligatory intracellular bacteria that infect a great number of species of arthropods and nematodes. In insects, they are mainly known for disrupting the reproductive biology of their hosts in order to...
Handbook of the Biology of Aging
Lower Organisms: Identification of Longevity. Assurance Genes in Yeast. Molecular Genetic Approaches to Identifying Gerontogenes in Caenorhabditis Elegans. Genetic Approaches to Life Prolongation in Drosophila Melonogaster. Mutants Affectin...
Human Disease Models in Drosophila melanogaster and the Role of the Fly in Therapeutic Drug Discovery
This 2011 review in Pharmacological Reviews examines the use of Drosophila melanogaster as a model organism for human disease and therapeutic development.
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
The target of rapamycin (TOR) pathway is a major nutrient-sensing pathway that, when genetically downregulated, increases life span in evolutionarily diverse organisms including mammals. The central component of this pathway, TOR kinase, is...
Lifespan and reproduction in Drosophila : New insights from nutritional geometry
Modest dietary restriction (DR) prolongs life in a wide range of organisms, spanning single-celled yeast to mammals. Here, we report the use of recent techniques in nutrition research to quantify the detailed relationship between diet, nutr...
Sirtuin 2 Inhibitors Rescue α-Synuclein-Mediated Toxicity in Models of Parkinson's Disease
The sirtuins are members of the histone deacetylase family of proteins that participate in a variety of cellular functions and play a role in aging. We identified a potent inhibitor of sirtuin 2 (SIRT2) and found that inhibition of SIRT2 re...
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
Research published in Nature in 2004 examines the role of Drosophila dFOXO in regulating insulin signaling and influencing lifespan in the brain and fat body.