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Evidence brief · intervention

Metformin

Synthesized from 10 indexed sources · 2026-07-27 MST · preview (no AI key)
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Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].

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Sources

  1. [1] The mechanisms of action of metformin
  2. [2] Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota
  3. [3] Interventions for treating obesity in children
  4. [4] Metformin improves healthspan and lifespan in mice
  5. [5] Epigenetic clock analysis of diet, exercise, education, and lifestyle factors
  6. [6] Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status
  7. [7] Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1
  8. [8] Metformin: update on mechanisms of action and repurposing potential
  9. [9] Mitophagy in Macrophages: A Metabolic Checkpoint in Inflammation‐to‐Repair Transition in Atherosclerosis
  10. [10] Metformin attenuates cuprizone-induced mitochondrial dysfunction and senescence-associated changes in primary neuronal cells.
All Metformin works → Intervention dossier →