Model organism
Mouse
- Works
- 2,911
- Most cited
- 66,557
Most-cited works
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan,...
Inference and analysis of cell-cell communication using CellChat
Understanding global communications among cells requires accurate representation of cell-cell signaling links and effective systems-level analyses of those links. We construct a database of interactions among ligands, receptors and their co...
The amyloid hypothesis of Alzheimer's disease at 25 years
Despite continuing debate about the amyloid β-protein (or Aβ hypothesis, new lines of evidence from laboratories and clinics worldwide support the concept that an imbalance between production and clearance of Aβ42 and related Aβ peptides is...
Astrocytes: biology and pathology
Astrocytes are specialized glial cells that outnumber neurons by over fivefold. They contiguously tile the entire central nervous system (CNS) and exert many essential complex functions in the healthy CNS. Astrocytes respond to all forms of...
Resveratrol improves health and survival of mice on a high-calorie diet
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
Antibodies targeting CTLA-4 have been successfully used as cancer immunotherapy. We find that the antitumor effects of CTLA-4 blockade depend on distinct Bacteroides species. In mice and patients, T cell responses specific for B. thetaiotao...
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a tremendous impact on quality of life and the burden of age-related chronic diseases. Here,...
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase
Abstract mTORC1 is an important regulator of muscle mass but how it is modulated by oxygen and nutrients is not completely understood. We show that loss of the prolyl hydroxylase domain isoform 1 oxygen sensor in mice (PHD1 KO ) reduces mus...
TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use
Somatic mutations in the TP53 gene are one of the most frequent alterations in human cancers, and germline mutations are the underlying cause of Li-Fraumeni syndrome, which predisposes to a wide spectrum of early-onset cancers. Most mutatio...