Intervention
Caloric restriction
- Works
- 78
- Clinical trials
- 3
- Total citations
- 30,665
- Open access
- 66
Evidence brief
previewSynthesis (preview — no live AI key for the active provider):
Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].
Publication velocity
19852026
Clinical trials
The University of Texas Health Science Center at San Antonio 2020
Open access · US-GOV
Effect of SGLT2 Inhibition on Aging-related Biomarkers in Older Obese Adults With Pre-diabetes
University of Chile 2013
Open access · US-GOV
Mitochondrial Biogenesis, Reduction of Muscle Oxidative Damage and Improvement in Adipose Tissue Functional Profile, Account for the Beneficial Effects of Exercise and Healthy Diets
University of Chile 2012
Open access · US-GOV
Calorie Restriction Retards the Aging Process by Inducing Sirtuins and Uncoupling Protein 3, Thereby Reducing the Production of Reactive Oxygen Species.
Most-cited works
Physiological Reviews 1998
Citation only
The Free Radical Theory of Aging Matures
Science 1996
Preprint · OA
Oxidative Stress, Caloric Restriction, and Aging
Science 1997
Citation only
<i>daf-2</i> , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in <i>Caenorhabditis elegans</i>
Signal Transduction and Targeted Therapy 2022
Open access · CC-BY
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
Journal of Clinical Investigation 2004
Open access · OA
Ink4a/Arf expression is a biomarker of aging
Science 2003
Citation only
Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue
Genes & Development 2006
Open access · OA
Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction
Nature Reviews Molecular Cell Biology 2005
Citation only
Calorie restriction, SIRT1 and metabolism: understanding longevity
Journal of Nutrition 1986
Citation only
The Retardation of Aging in Mice by Dietary Restriction: Longevity, Cancer, Immunity and Lifetime Energy Intake
Genes & Development 2012
Open access · OA