Intervention
Caloric restriction
- Works
- 1,121
- Clinical trials
- 5
- Total citations
- 156,922
- Open access
- 994
Evidence brief
previewSynthesis (preview — no live AI key for the active provider):
Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].
Publication velocity
19772026
Clinical trials
Hospital Clinic of Barcelona 2020
Open access · US-GOV
Effect of Protein Supplementation and a Structured Physical Exercise Program on Changes in Body Composition, Metabolic Flexibility (Energy Consumption of Substrates), and Functionality in Women During Weight Loss Induced by BS
The University of Texas Health Science Center at San Antonio 2020
Open access · US-GOV
Effect of SGLT2 Inhibition on Aging-related Biomarkers in Older Obese Adults With Pre-diabetes
University of Chile 2013
Open access · US-GOV
Mitochondrial Biogenesis, Reduction of Muscle Oxidative Damage and Improvement in Adipose Tissue Functional Profile, Account for the Beneficial Effects of Exercise and Healthy Diets
University of Chile 2012
Open access · US-GOV
Calorie Restriction Retards the Aging Process by Inducing Sirtuins and Uncoupling Protein 3, Thereby Reducing the Production of Reactive Oxygen Species.
University Hospital Muenster 2009
Open access · US-GOV
Phase IV Interventional Study: Effects of Dietary Interventions on Brain Functions in Healthy Elderly People
Most-cited works
Physiological Reviews 1998
Citation only
The Free Radical Theory of Aging Matures
Science 1996
Preprint · OA
Oxidative Stress, Caloric Restriction, and Aging
Pharmaceutical Research 2008
Open access · CC-BY
Cancer is a Preventable Disease that Requires Major Lifestyle Changes
Science 2009
Preprint · OA
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Science 1997
Citation only
<i>daf-2</i> , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in <i>Caenorhabditis elegans</i>
Nature 2004
Citation only
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Signal Transduction and Targeted Therapy 2022
Open access · CC-BY
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
Journal of Clinical Investigation 2004
Open access · OA
Ink4a/Arf expression is a biomarker of aging
Science 2003
Citation only
Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue
Genes & Development 2006
Preprint · OA