C. elegans

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it...

<i>daf-2</i> , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in <i>Caenorhabditis elegans</i>

A C. elegans neurosecretory signaling system regulates whether animals enter the reproductive life cycle or arrest development at the long-lived dauer diapause stage. daf-2, a key gene in the genetic pathway that mediates this endocrine sig...

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

The aging process.

Aging is the progressive accumulation of changes with time that are associated with or responsible for the ever-increasing susceptibility to disease and death which accompanies advancing age. These time-related changes are attributed to the...

Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

The Caenorhabditis elegans transcription factor HSF-1, which regulates the heat-shock response, also influences aging. Reducing hsf-1 activity accelerates tissue aging and shortens life-span, and we show that hsf-1 overexpression extends li...

Handbook of the Biology of Aging

Lower Organisms: Identification of Longevity. Assurance Genes in Yeast. Molecular Genetic Approaches to Identifying Gerontogenes in Caenorhabditis Elegans. Genetic Approaches to Life Prolongation in Drosophila Melonogaster. Mutants Affectin...

Direct Inhibition of the Longevity-Promoting Factor SKN-1 by Insulin-like Signaling in C. elegans

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

Regulation of Longevity and Stress Resistance by Sch9 in Yeast

The protein kinase Akt/protein kinase B (PKB) is implicated in insulin signaling in mammals and functions in a pathway that regulates longevity and stress resistance in Caenorhabditis elegans. We screened for long-lived mutants in nondividi...

Long live <scp>FOXO</scp> : unraveling the role of <scp>FOXO</scp> proteins in aging and longevity

Aging constitutes the key risk factor for age-related diseases such as cancer and cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are complex phenotypes influenced by both environmental and genetic factors....

Collapse of proteostasis represents an early molecular event in <i>Caenorhabditis elegans</i> aging

Protein damage contributes prominently to cellular aging. To address whether this occurs at a specific period during aging or accumulates gradually, we monitored the biochemical, cellular, and physiological properties of folding sensors exp...

Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

Metformin, a biguanide drug commonly used to treat type-2 diabetes, has been noted to extend healthspan of nondiabetic mice, but this outcome, and the molecular mechanisms that underlie it, have received relatively little experimental atten...