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The map of aging research
The record organized around the biological hallmarks of aging. Each cluster is grounded in vector embeddings — its highlighted works sit nearest the cluster's semantic centre. Click a cluster to explore its evidence. 3,769 works mapped.
Cellular senescence
Accumulation of growth-arrested “zombie” cells.
- Cellular Senescence in Cancer and Aging
- Cellular senescence and the aging brain
- Significance of Cellular Senescence in Aging and Cancer
Mitochondrial dysfunction
Failing cellular energy production.
- Aging Hallmarks and the Role of Oxidative Stress
- Enhancing mitochondrial quality control to fight neuromuscular degener...
- Mitochondrial Aging in the CNS: Unravelling Implications for Neurologi...
Epigenetic alterations
Drift in methylation and chromatin state.
- Epigenetic Mechanisms in Aging: Extrinsic Factors and Gut Microbiome
- DNA Methylation Array Analysis Identifies Profiles of Blood-Derived DN...
- Genomic Instability and Epigenetic Changes during Aging
Chronic inflammation
“Inflammaging” — sustained low-grade inflammation.
- Protective Role of Polyphenols against Vascular Inflammation, Aging an...
- Aging Hallmarks and the Role of Oxidative Stress
- Mitochondrial dysfunction in the regulation of aging and aging-related...
Telomere attrition
Progressive shortening of chromosome end-caps.
- Telomere length and cardiovascular aging
- Accelerated telomere shortening in response to life stress
- Telomeres and Aging
Genomic instability
Accumulation of DNA damage across the genome.
- Delayed kinetics of DNA double‐strand break processing in normal and p...
- Role of mismatch repair in aging
- DNA Repair Defects in Stem Cell Function and Aging
Altered intercellular communication
Chronic inflammation and signaling shifts.
- Cellular Homeostasis and Aging
- Current aspects of targeting cellular senescence for the therapy of ne...
- Redox control of senescence and age-related disease
Disabled macroautophagy
Impaired cellular self-clearance.
- Autophagy: A Key Regulator of Homeostasis and Disease: An Overview of...
- Transcriptional Dysregulation of Autophagy in Aging and Potential Inte...
- Molecular and cellular pathways contributing to brain aging
Loss of proteostasis
Decline in protein quality control.
- Walking the tightrope: proteostasis and neurodegenerative disease
- Proteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative...
- Enhancing mitochondrial quality control to fight neuromuscular degener...
Dysbiosis
Disruption of the microbiome.
- Enhancing Cognition in Older Adults With Intermittent Hypoxia and Cogn...
- Effect of a Social Cognitive Theory-Based Education Program on Self-Ef...
- B-Fit Intervention to Improve Engagement in Healthy Brain Aging Activi...
Stem-cell exhaustion
Decline in regenerative cell pools.
- Systemic aging delay and anti-aging therapy using allogeneic stem cell...
- DNA Repair Defects in Stem Cell Function and Aging
- Age-related changes in mesenchymal stem cells identified using a multi...
Deregulated nutrient-sensing
Dysregulated mTOR, AMPK, IGF-1 signaling.
- mTOR and Aging: An Old Fashioned Dress
- The Multifaceted Role of Nutrient Sensing and mTORC1 Signaling in Phys...
- Mechanisms of Dysfunction in the Aging Vasculature and Role in Age-Rel...