Explore
The map of aging research
The record organized around the biological hallmarks of aging. Each cluster is grounded in vector embeddings — its highlighted works sit nearest the cluster's semantic centre. Click a cluster to explore its evidence. 34,683 works mapped.
Chronic inflammation
“Inflammaging” — sustained low-grade inflammation.
- Inflammaging in Cardiovascular Disease: Emerging Mechanisms and Therap...
- Editorial: Inflammaging and immunosenescence: role in aging-associated...
- Redox Homeostasis and Cellular Stress Response in Aging and Neurodegen...
Dysbiosis
Disruption of the microbiome.
- The association between frailty and severe disease among COVID-19 pati...
- Frailty, Chronological Age, and Clinical Outcomes in COPD : A Nationwi...
- Author response: Regulation of life span by the gut microbiota in the...
Mitochondrial dysfunction
Failing cellular energy production.
- Mitochondrial Health in Aging and Age‐Related Metabolic Disease
- Targeting mitophagy for neuroprotection: mechanisms and therapeutic op...
- Editorial: Genetic and molecular mechanisms of healthy aging and age-r...
Cellular senescence
Accumulation of growth-arrested “zombie” cells.
- The Aging of Cells: Cellular Senescence and Implications for Age-Relat...
- Targeting Senescent Cells: Possible Implications for Delaying Skin Agi...
- Targeting cellular senescence in cancer and aging: roles of p53 and it...
Epigenetic alterations
Drift in methylation and chromatin state.
- The Epigenetic Landscape: From Molecular Mechanisms to Biological Agin...
- Editorial: DNA methylation: The aging clock
- DNA methylation clocks for estimating biological age in Chinese cohort...
Altered intercellular communication
Chronic inflammation and signaling shifts.
- Editorial: Genetic and molecular mechanisms of healthy aging and age-r...
- Redox Homeostasis and Cellular Stress Response in Aging and Neurodegen...
- Oxidative Stress in Aging
Deregulated nutrient-sensing
Dysregulated mTOR, AMPK, IGF-1 signaling.
- Editorial: Genetic and molecular mechanisms of healthy aging and age-r...
- Phloretic acid requires the insulin/IGF-1 pathway and autophagy to enh...
- Pleiotropic Effects of mTOR and Autophagy During Development and Aging
Stem-cell exhaustion
Decline in regenerative cell pools.
- Stem Cells and Aging
- Stem Cells in Aging and Anti-Aging.
- Systemic aging delay and anti-aging therapy using allogeneic stem cell...
Loss of proteostasis
Decline in protein quality control.
- How do proteins shape our lifespan? Exploring aging at the molecular l...
- Walking the tightrope: proteostasis and neurodegenerative disease
- Analysis of protein levels and solubility in distinct brain regions re...
Disabled macroautophagy
Impaired cellular self-clearance.
- Mitochondrial Health in Aging and Age‐Related Metabolic Disease
- Pleiotropic Effects of mTOR and Autophagy During Development and Aging
- Autophagic mechanisms in longevity intervention: role of natural activ...
Telomere attrition
Progressive shortening of chromosome end-caps.
- Telomere-A Short Review
- Telomeres and Aging
- Accelerated telomere shortening in response to life stress
Genomic instability
Accumulation of DNA damage across the genome.
- DNA Repair Defects in Stem Cell Function and Aging
- The Role of DNA Damage and Nutritional Interventions in Aging in Proge...
- Delayed kinetics of DNA double‐strand break processing in normal and p...