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The map of aging research
The record organized around the biological hallmarks of aging. Each cluster is grounded in vector embeddings — its highlighted works sit nearest the cluster's semantic centre. Click a cluster to explore its evidence. 19,708 works mapped.
Chronic inflammation
“Inflammaging” — sustained low-grade inflammation.
- Protective Role of Polyphenols against Vascular Inflammation, Aging an...
- Targeting Cellular Senescence for Healthy Aging: Advances in Senolytic...
- Gene Expression Profile in Major Depressive Disorder Shows Reduced Mit...
Mitochondrial dysfunction
Failing cellular energy production.
- Mitophagy: An Emerging Role in Aging and Age-Associated Diseases
- Aging Hallmarks and the Role of Oxidative Stress
- Enhancing mitochondrial quality control to fight neuromuscular degener...
Cellular senescence
Accumulation of growth-arrested “zombie” cells.
- Targeting Senescent Cells: Possible Implications for Delaying Skin Agi...
- Targeting cellular senescence in cancer and aging: roles of p53 and it...
- Cellular senescence in cancer: molecular mechanisms and therapeutic ta...
Altered intercellular communication
Chronic inflammation and signaling shifts.
- Diet and Aging
- Pleiotropic Effects of mTOR and Autophagy During Development and Aging
- Cellular Homeostasis and Aging
Epigenetic alterations
Drift in methylation and chromatin state.
- Epigenetic Aging: More Than Just a Clock When It Comes to Cancer
- DNA Methylation, Aging, and Cancer
- A Meta-Analysis of Brain DNA Methylation Across Sex, Age, and Alzheime...
Deregulated nutrient-sensing
Dysregulated mTOR, AMPK, IGF-1 signaling.
- Pleiotropic Effects of mTOR and Autophagy During Development and Aging
- Usnic Acid extends healthspan and improves the neurodegeneration disea...
- Taurine and Berberine: Nutritional Interventions Targeting Cellular Me...
Stem-cell exhaustion
Decline in regenerative cell pools.
- Stem Cells and Aging
- Rejuvenation of Tissue Stem Cells by Intrinsic and Extrinsic Factors
- Stem Cells in Aging and Anti-Aging.
Dysbiosis
Disruption of the microbiome.
- Author response: Regulation of life span by the gut microbiota in the...
- Early Biomarkers, Risk Factors, and Functional Indicators of Healthy L...
- The Effects of Lifestyle and Diet on Gut Microbiota Composition, Infla...
Disabled macroautophagy
Impaired cellular self-clearance.
- Pleiotropic Effects of mTOR and Autophagy During Development and Aging
- New Insights into the Role of Mitochondrial Dynamics and Autophagy dur...
- Defective Autophagy and Mitophagy in Aging and Alzheimer’s Disease
Telomere attrition
Progressive shortening of chromosome end-caps.
- Telomeres and Aging
- Telomeres, stem cells, and hematology
- Accelerated telomere shortening in response to life stress
Genomic instability
Accumulation of DNA damage across the genome.
- Delayed kinetics of DNA double‐strand break processing in normal and p...
- DNA damage response and cellular senescence in tissues of aging mice
- DNA Repair Defects in Stem Cell Function and Aging
Loss of proteostasis
Decline in protein quality control.
- Walking the tightrope: proteostasis and neurodegenerative disease
- MicroRNAs in Age-Related Proteostasis and Stress Responses
- Proteostasis Failure in Neurodegenerative Diseases: Focus on Oxidative...