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Epigenetic clock analysis of diet, exercise, education, and lifestyle factors

Austin Quach, Morgan E. Levine, Toshiko Tanaka, Ake T. Lu, Brian H. Chen, Luigi Ferrucci, Beate Ritz, Stefania Bandinelli, Marian L. Neuhouser, Jeannette M. Beasley, Linda Snetselaar, Robert B. Wallace, Philip S. Tsao, Devin Absher, Themistocles L. Assimes

Aging · 2017 · ▲ 895 citations

Epigenetic alterations Metformin Exercise

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Abstract

)-an indicator of fruit and vegetable consumption, whereas intrinsic epigenetic age acceleration (IEAA) is associated with poultry intake (p=0.03) and BMI (p=0.05). Both EEAA and IEAA were also found to relate to indicators of metabolic syndrome, which appear to mediate their associations with BMI. Metformin-the first-line medication for the treatment of type 2 diabetes-does not delay epigenetic aging in this observational study. Finally, longitudinal data suggests that an increase in BMI is associated with increase in both EEAA and IEAA.Overall, the epigenetic age analysis of blood confirms the conventional wisdom regarding the benefits of eating a high plant diet with lean meats, moderate alcohol consumption, physical activity, and education, as well as the health risks of obesity and metabolic syndrome.

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Provenance

Source: OpenAlex
DOI: 10.18632/aging.101168
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Fetched: 2026-07-22 MST

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APA

Quach, A., Levine, M.E., Tanaka, T., Lu, A.T., Chen, B.H., Ferrucci, L., Ritz, B., Bandinelli, S., Neuhouser, M.L., Beasley, J.M., Snetselaar, L., Wallace, R.B., Tsao, P.S., Absher, D., Assimes, T.L., Stewart, J.D., Li, Y., Hou, L., Baccarelli, A., & Whitsel, E.A. (2017). Epigenetic clock analysis of diet, exercise, education, and lifestyle factors. <em>Aging</em>. https://doi.org/10.18632/aging.101168

Vancouver

Quach A, Levine ME, Tanaka T, Lu AT, Chen BH, Ferrucci L, et al. Epigenetic clock analysis of diet, exercise, education, and lifestyle factors. Aging. 2017. doi:10.18632/aging.101168.

BibTeX

@article{austin2017Epigen, title = {Epigenetic clock analysis of diet, exercise, education, and lifestyle factors}, author = {Austin Quach and Morgan E. Levine and Toshiko Tanaka and Ake T. Lu and Brian H. Chen and Luigi Ferrucci and Beate Ritz and Stefania Bandinelli and Marian L. Neuhouser and Jeannette M. Beasley and Linda Snetselaar and Robert B. Wallace and Philip S. Tsao and Devin Absher and Themistocles L. Assimes and James D. Stewart and Yun Li and Lifang Hou and Andrea Baccarelli and Eric A. Whitsel and Steve Horvath}, journal = {Aging}, year = {2017}, doi = {10.18632/aging.101168}, }