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Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction

Genes & Development · 2006 · ▲ 1,300 citations

Deregulated nutrient-sensing Caloric restriction Yeast Review

Abstract

Sir2 is an NAD-dependent deacetylase that connects metabolism with longevity in yeast, worms and flies. Mammals contain seven homologs of yeast Sir2, SIRT1-7. Here, we review recent findings demonstrating the role of these mammalian sirtuins as regulators of physiology, calorie restriction, and aging. The current findings sharpen our understanding of sirtuins as potential pharmacological targets to treat the major diseases of aging.

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Provenance

Source: OpenAlex
DOI: 10.1101/gad.1467506
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Fetched: 2026-07-16 MST

Cite this

APA

Haigis, M.C., & Guarente, L. (2006). Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction. <em>Genes & Development</em>. https://doi.org/10.1101/gad.1467506

Vancouver

Haigis MC, Guarente L. Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction. Genes & Development. 2006. doi:10.1101/gad.1467506.

BibTeX

@unpublished{marcia2006Mammal, title = {Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction}, author = {Marcia C. Haigis and Leonard Guarente}, journal = {Genes & Development}, year = {2006}, doi = {10.1101/gad.1467506}, }