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Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

Ricki J. Colman, Rozalyn M. Anderson, Sterling C. Johnson, Erik K. Kastman, Kristopher J. Kosmatka, T. Mark Beasley, David B. Allison, Christina Cruzen, Heather A. Simmons, Joseph W. Kemnitz, Richard Weindruch

Science · 2009 · ▲ 2,282 citations

Deregulated nutrient-sensing Caloric restriction Non-human primate

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Abstract

Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established. We report findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research. In a population of rhesus macaques maintained at the Wisconsin National Primate Research Center, moderate CR lowered the incidence of aging-related deaths. At the time point reported, 50% of control fed animals survived as compared with 80% of the CR animals. Furthermore, CR delayed the onset of age-associated pathologies. Specifically, CR reduced the incidence of diabetes, cancer, cardiovascular disease, and brain atrophy. These data demonstrate that CR slows aging in a primate species.

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Provenance

Source: OpenAlex
DOI: 10.1126/science.1173635
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Fetched: 2026-07-22 MST

Cite this

APA

Colman, R.J., Anderson, R.M., Johnson, S.C., Kastman, E.K., Kosmatka, K.J., Beasley, T.M., Allison, D.B., Cruzen, C., Simmons, H.A., Kemnitz, J.W., & Weindruch, R. (2009). Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys. <em>Science</em>. https://doi.org/10.1126/science.1173635

Vancouver

Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, et al. Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys. Science. 2009. doi:10.1126/science.1173635.

BibTeX

@unpublished{ricki2009Calori, title = {Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys}, author = {Ricki J. Colman and Rozalyn M. Anderson and Sterling C. Johnson and Erik K. Kastman and Kristopher J. Kosmatka and T. Mark Beasley and David B. Allison and Christina Cruzen and Heather A. Simmons and Joseph W. Kemnitz and Richard Weindruch}, journal = {Science}, year = {2009}, doi = {10.1126/science.1173635}, }