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Evidence brief · intervention

Caloric restriction

Synthesized from 10 indexed sources · 2026-06-03 MST · preview (no AI key)
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Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].

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Sources

  1. [1] The Free Radical Theory of Aging Matures
  2. [2] Oxidative Stress, Caloric Restriction, and Aging
  3. [3] <i>daf-2</i> , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in <i>Caenorhabditis elegans</i>
  4. [4] Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
  5. [5] Ink4a/Arf expression is a biomarker of aging
  6. [6] Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue
  7. [7] Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction
  8. [8] Calorie restriction, SIRT1 and metabolism: understanding longevity
  9. [9] Integrative Omics Reveal Female-Specific Benefits of p16&lt;sup&gt;+&lt;/sup&gt; Cell Clearance in Aging Mice.
  10. [10] Multilayered regulation of longevity in Caenorhabditis elegans.
All Caloric restriction works → Intervention dossier →