Intervention
Spermidine
- Works
- 190
- Clinical trials
- 1
- Total citations
- 14,194
- Open access
- 175
Evidence brief
previewSynthesis (preview — no live AI key for the active provider):
Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].
Publication velocity
20092026
Clinical trials
Icahn School of Medicine at Mount Sinai 2025
Open access · US-GOV
A Phase 1b, Multi-cohort Clinical Trial Assessing Safety and Feasibility of Exercise and Spermidine Administered in Conjunction With Lamivudine (RTi) or Rapamycin (mTORi) to Assess Impact on Dynamic Changes of Inflammation and Aging
Most-cited works
Nature Cell Biology 2009
Open access · OA
Induction of autophagy by spermidine promotes longevity
Nature Medicine 2016
Preprint · OA
Cardioprotection and lifespan extension by the natural polyamine spermidine
Aging 2011
Open access · CC-BY
Polyamines in aging and disease
The Journal of Cell Biology 2011
Open access · OA
Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome
Cell Death and Differentiation 2014
Preprint · OA
Spermidine induces autophagy by inhibiting the acetyltransferase EP300
Scientific Reports 2014
Open access · CC-BY
Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice
Frontiers in Nutrition 2019
Open access · CC-BY
Polyamines in Food
Nature Communications 2021
Open access · CC-BY
Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon
Circulation Research 2018
Citation only
Autophagy in Cardiovascular Aging
Frontiers in Nutrition 2019
Open access · CC-BY