Intervention
Spermidine
- Works
- 8
- Clinical trials
- 1
- Total citations
- 2,214
- Open access
- 8
Evidence brief
previewSynthesis (preview — no live AI key for the active provider):
Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].
Publication velocity
20092026
Clinical trials
Icahn School of Medicine at Mount Sinai 2025
Open access · US-GOV
A Phase 1b, Multi-cohort Clinical Trial Assessing Safety and Feasibility of Exercise and Spermidine Administered in Conjunction With Lamivudine (RTi) or Rapamycin (mTORi) to Assess Impact on Dynamic Changes of Inflammation and Aging
Most-cited works
Nature Cell Biology 2009
Open access · OA
Induction of autophagy by spermidine promotes longevity
Circulation Research 2019
Open access · OA
Age-Associated Mitochondrial Dysfunction Accelerates Atherogenesis
Cell Proliferation 2020
Open access · CC-BY
S‐adenosylmethionine: A metabolite critical to the regulation of autophagy
Acta Pharmacologica Sinica 2013
Open access · CC-BY
Autophagy in ageing and ageing-associated diseases
Biomedicine & Pharmacotherapy 2022
Open access · CC-BY
Are mitophagy enhancers therapeutic targets for Alzheimer’s disease?
Geromedicine 2025
Open access · CC-BY
Autophagy in age-related liver disease
Icahn School of Medicine at Mount Sinai 2025
Open access · US-GOV
A Phase 1b, Multi-cohort Clinical Trial Assessing Safety and Feasibility of Exercise and Spermidine Administered in Conjunction With Lamivudine (RTi) or Rapamycin (mTORi) to Assess Impact on Dynamic Changes of Inflammation and Aging
Amino acids 2026
Open access · OA