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Evidence brief · intervention

Spermidine

Synthesized from 8 indexed sources · 2026-06-03 MST · preview (no AI key)
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Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].

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Sources

  1. [1] Induction of autophagy by spermidine promotes longevity
  2. [2] Age-Associated Mitochondrial Dysfunction Accelerates Atherogenesis
  3. [3] S‐adenosylmethionine: A metabolite critical to the regulation of autophagy
  4. [4] Autophagy in ageing and ageing-associated diseases
  5. [5] Are mitophagy enhancers therapeutic targets for Alzheimer’s disease?
  6. [6] Autophagy in age-related liver disease
  7. [7] A Phase 1b, Multi-cohort Clinical Trial Assessing Safety and Feasibility of Exercise and Spermidine Administered in Conjunction With Lamivudine (RTi) or Rapamycin (mTORi) to Assess Impact on Dynamic Changes of Inflammation and Aging
  8. [8] Polyamine metabolism as a regulator of cellular and organismal aging.
All Spermidine works → Intervention dossier →