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Evidence brief · intervention

Spermidine

Synthesized from 10 indexed sources · 2026-07-26 MST · preview (no AI key)
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Across the retrieved literature, senescent-cell burden and chronic inflammation recur as central, interacting drivers, with intervention studies reporting functional gains in model organisms. Key works: [1][2][3][4][5].

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Sources

  1. [1] Induction of autophagy by spermidine promotes longevity
  2. [2] Cardioprotection and lifespan extension by the natural polyamine spermidine
  3. [3] Polyamines in aging and disease
  4. [4] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome
  5. [5] Spermidine induces autophagy by inhibiting the acetyltransferase EP300
  6. [6] Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice
  7. [7] Polyamines in Food
  8. [8] Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon
  9. [9] Unusually High Enrichment of Bioactive Components for Healthy Aging and Longevity in Natto, a Fermented Soybean Food
  10. [10] Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults-A Pilot Study.
All Spermidine works → Intervention dossier →