Open access · CC-BY via OpenAlex

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

Mikołaj Ogrodnik, Yi Zhu, Larissa Prata, Tamar Tchkonia, Patrick Krüger, Edward Fielder, Stella Victorelli, Rifqha A. Ruswhandi, Nino Giorgadze, Tamar Pirtskhalava, Oleg Podgorni, Grigori Enikolopov, Kurt O. Johnson, Ming Xu, Christine Inman

Cell Metabolism · 2019 · ▲ 538 citations

Cellular senescence Senolytics Mouse

＋ Sign in to save

Abstract

-expressing senescent cells can be eliminated, and senolytic drugs dasatinib and quercetin. We found that obesity results in the accumulation of senescent glial cells in proximity to the lateral ventricle, a region in which adult neurogenesis occurs. Furthermore, senescent glial cells exhibit excessive fat deposits, a phenotype we termed "accumulation of lipids in senescence." Clearing senescent cells from high fat-fed or leptin receptor-deficient obese mice restored neurogenesis and alleviated anxiety-related behavior. Our study provides proof-of-concept evidence that senescent cells are major contributors to obesity-induced anxiety and that senolytics are a potential new therapeutic avenue for treating neuropsychiatric disorders.

◌ CITATION ONLY
Full text is not openly licensed for redistribution here. Read it at the source:

Read at source →

Provenance

Source: OpenAlex
DOI: 10.1016/j.cmet.2018.12.008
Canonical: link ↗
Fetched: 2026-06-14 MST

Cite this

APA

Ogrodnik, M., Zhu, Y., Prata, L., Tchkonia, T., Krüger, P., Fielder, E., Victorelli, S., Ruswhandi, R.A., Giorgadze, N., Pirtskhalava, T., Podgorni, O., Enikolopov, G., Johnson, K.O., Xu, M., Inman, C., Palmer, A.K., Schafer, M., Weigl, M., Ikeno, Y., & Burns, T.C. (2019). Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis. <em>Cell Metabolism</em>. https://doi.org/10.1016/j.cmet.2018.12.008

Vancouver

Ogrodnik M, Zhu Y, Prata L, Tchkonia T, Krüger P, Fielder E, et al. Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis. Cell Metabolism. 2019. doi:10.1016/j.cmet.2018.12.008.

BibTeX

@article{mikoaj2019Obesit, title = {Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis}, author = {Mikołaj Ogrodnik and Yi Zhu and Larissa Prata and Tamar Tchkonia and Patrick Krüger and Edward Fielder and Stella Victorelli and Rifqha A. Ruswhandi and Nino Giorgadze and Tamar Pirtskhalava and Oleg Podgorni and Grigori Enikolopov and Kurt O. Johnson and Ming Xu and Christine Inman and Allyson K. Palmer and Marissa Schafer and Moritz Weigl and Yuji Ikeno and Terry C. Burns and João F. Passos and Thomas von Zglinicki and James L. Kirkland and Diana Jurk}, journal = {Cell Metabolism}, year = {2019}, doi = {10.1016/j.cmet.2018.12.008}, }