Hallmark of aging · H08
Cellular senescence
Accumulation of growth-arrested “zombie” cells.
- Works
- 5,565
- Most cited
- 8,440
Most-cited works
Aging: A Theory Based on Free Radical and Radiation Chemistry
The phenomenon of growth, decline and death—aging—has been the source of considerable speculation (1, 8, 10). This cycle seems to be a more or less direct function of the metabolic rate and this in turn depends on the species (animal or pla...
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Normal somatic cells invariably enter a state of irreversibly arrested growth and altered function after a finite number of divisions. This process, termed replicative senescence, is thought to be a tumor-suppressive mechanism and an underl...
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
In this paper we extend the "network theory of aging," and we argue that a global reduction in the capacity to cope with a variety of stressors and a concomitant progressive increase in proinflammatory status are major characteristics of th...
Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a
A 1997 Cell study demonstrates that oncogenic ras induces premature cell senescence through the accumulation of p53 and p16INK4a proteins.
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
Cellular senescence is a tumor-suppressive mechanism that permanently arrests cells at risk for malignant transformation. However, accumulating evidence shows that senescent cells can have deleterious effects on the tissue microenvironment....
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Normal human cells undergo a finite number of cell divisions and ultimately enter a nondividing state called replicative senescence. It has been proposed that telomere shortening is the molecular clock that triggers senescence. To test this...
Leaf Senescence: Correlated with Increased Levels of Membrane Permeability and Lipid Peroxidation, and Decreased Levels of Superoxide Dismutase and Catalase
The changes in membrane permeability (soluble leakage), lipid peroxidation, and activities of superoxide dismutase (SOD) and catalase have been studied during in situ senescence of leaves of Nicotiana tabacum L., cv. Wisconsin 38. After ful...
Cellular senescence: when bad things happen to good cells
Explore how cellular senescence halts damaged cell proliferation, its role in aging and cancer, and the mechanisms driving tissue degeneration.
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
Cellular senescence suppresses cancer by arresting cell proliferation, essentially permanently, in response to oncogenic stimuli, including genotoxic stress. We modified the use of antibody arrays to provide a quantitative assessment of fac...
PLEIOTROPY, NATURAL SELECTION, AND THE EVOLUTION OF SENESCENCE
Explore George C. Williams's 1957 seminal *Evolution* paper on antagonistic pleiotropy, natural selection, and the evolutionary origins of senescence.
The Free Radical Theory of Aging Matures
The free radical theory of aging, conceived in 1956, has turned 40 and is rapidly attracting the interest of the mainstream of biological research. From its origins in radiation biology, through a decade or so of dormancy and two decades of...
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Removing p16Ink4a-positive senescent cells delays the onset of multiple aging-associated disorders in mice, highlighting a potential anti-aging strategy.