Tamar Pirtskhalava

Aging Cell · 2015

⊕ Open access · CC-BY

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

▲ 2,528

Nature Medicine · 2018

⊕ Preprint · OA

Senolytics improve physical function and increase lifespan in old age

▲ 2,334

Nature Communications · 2017

⊕ Open access · CC-BY

Cellular senescence mediates fibrotic pulmonary disease

▲ 1,638

EBioMedicine · 2019

⊕ Open access · CC-BY

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

▲ 1,368

Aging Cell · 2015

⊕ Open access · CC-BY

Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors

▲ 1,142

Nature Medicine · 2017

⊕ Preprint · OA

Targeting cellular senescence prevents age-related bone loss in mice

▲ 1,131

EBioMedicine · 2018

⊕ Open access · CC-BY

Fisetin is a senotherapeutic that extends health and lifespan

▲ 1,036

Proceedings of the National Academy of Sciences · 2015

⊕ Open access · OA

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

▲ 932

Aging · 2017

⊕ Open access · CC-BY

New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

▲ 745

Aging Cell · 2016

⊕ Open access · CC-BY

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

▲ 744

Aging Cell · 2019

⊕ Open access · CC-BY

Targeting senescent cells alleviates obesity‐induced metabolic dysfunction

▲ 687

eLife · 2015

⊕ Open access · CC-BY

Targeting senescent cells enhances adipogenesis and metabolic function in old age

▲ 605

Cell Metabolism · 2019

⊕ Open access · CC-BY

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

▲ 553

Aging Cell · 2021

⊕ Open access · CC-BY

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice

▲ 418

The Journals of Gerontology Series A · 2016

⊕ Open access · CC-BY

17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization

▲ 129

EBioMedicine · 2022

⊕ Open access · CC-BY

Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans

▲ 96

Aging · 2021

⊕ Open access · CC-BY

SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3

▲ 90

EBioMedicine · 2025

⊕ Open access · CC-BY

A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer’s disease

▲ 82

EBioMedicine · 2020

⊕ Open access · CC-BY

Corrigendum to ‘Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease’ EBioMedicine 47 (2019) 446–456

▲ 59

Cell Metabolism · 2024

⊕ Preprint · OA

Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function

▲ 56

Cell Metabolism · 2025

⊕ Preprint · OA

Endothelial senescent-cell-specific clearance alleviates metabolic dysfunction in obese mice

▲ 19

Aging Cell · 2025

⊕ Open access · CC-BY

Senolytic‐Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing Senosensitizers

▲ 8

Innovation in Aging · 2020

⊕ Open access · CC-BY

Effect of Combined Dasatinib and Fisetin Treatment on Senescent Cell Clearance in Monkeys

▲ 2