Author
Tamar Tchkonia
- Indexed works
- 81
- Total citations
- 31,941
- Active years
- 16
Collaborators
Works in the record
Nature 2011
Preprint · OA
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Aging Cell 2015
Open access · CC-BY
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
Journal of Clinical Investigation 2013
Open access · OA
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
Nature Communications 2017
Open access · CC-BY
Cellular senescence mediates fibrotic pulmonary disease
EBioMedicine 2019
Open access · CC-BY
Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study
Journal of Internal Medicine 2020
Open access · CC-BY
Senolytic drugs: from discovery to translation
Nature Medicine 2017
Preprint · OA
Targeting cellular senescence prevents age-related bone loss in mice
Aging Cell 2015
Open access · CC-BY
Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors
Aging Cell 2010
Open access · OA
Fat tissue, aging, and cellular senescence
Nature Medicine 2022
Open access · OA
Cellular senescence and senolytics: the path to the clinic
Nature Communications 2017
Open access · CC-BY
Cellular senescence drives age-dependent hepatic steatosis
EBioMedicine 2017
Open access · OA
Cellular Senescence: A Translational Perspective
EBioMedicine 2018
Open access · OA
Fisetin is a senotherapeutic that extends health and lifespan
Nature Communications 2022
Open access · CC-BY
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
Proceedings of the National Academy of Sciences 2015
Open access · OA
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
Aging 2017
Open access · CC-BY
New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463
Aging Cell 2016
Open access · CC-BY
Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
Nature Communications 2017
Open access · CC-BY
Identification of HSP90 inhibitors as a novel class of senolytics
eLife 2015
Open access · CC-BY
Targeting senescent cells enhances adipogenesis and metabolic function in old age
Journal of Bone and Mineral Research 2016
Preprint · OA
Identification of Senescent Cells in the Bone Microenvironment
Cell Metabolism 2019
Open access · CC-BY
Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis
Nature Reviews Endocrinology 2020
Preprint · OA
The role of cellular senescence in ageing and endocrine disease
Diabetes 2015
Open access · OA
Cellular Senescence in Type 2 Diabetes: A Therapeutic Opportunity
Aging Cell 2021
Open access · CC-BY
Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice
The Annual Review of Pharmacology and Toxicology 2020
Open access · OA
Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span
Aging Cell 2019
Open access · CC-BY
Aged‐senescent cells contribute to impaired heart regeneration
Current Opinion in Clinical Nutrition & Metabolic Care 2014
Citation only
Cellular senescence and the senescent secretory phenotype in age-related chronic diseases
EBioMedicine 2023
Open access · OA
Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability
Nature Medicine 2023
Preprint · OA
Senolytic therapy in mild Alzheimer’s disease: a phase 1 feasibility trial
Diabetes 2016
Open access · OA
Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue
The Journals of Gerontology Series A 2021
Preprint · OA
Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice
Nature Communications 2020
Open access · CC-BY
Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation
The Journal of Prevention of Alzheimer s Disease 2021
Open access · OA
Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD): A Pilot Clinical Trial
Trends in Molecular Medicine 2020
Preprint · OA
Reducing Senescent Cell Burden in Aging and Disease
FEBS Journal 2020
Open access · CC-BY
Discovery, development, and future application of senolytics: theories and predictions
Nestlé Nutrition Institute Workshop series 2015
Preprint · OA
Cellular Senescence and the Biology of Aging, Disease, and Frailty
Nature reviews. Immunology 2022
Open access · OA
COVID-19 and cellular senescence
Journal of Bone and Mineral Research 2020
Open access · OA
Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy-Related Bone Loss
Biochemical and Biophysical Research Communications 2019
Open access · CC-BY
The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline
Advanced Science 2020
Open access · CC-BY
Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities
The Journals of Gerontology Series A 2016
Open access · CC-BY
17α-Estradiol Alleviates Age-related Metabolic and Inflammatory Dysfunction in Male Mice Without Inducing Feminization
The Journal of Clinical Endocrinology & Metabolism 2020
Open access · OA
New Horizons: Novel Approaches to Enhance Healthspan Through Targeting Cellular Senescence and Related Aging Mechanisms
Journal of Bone and Mineral Research 2019
Open access · OA
Independent Roles of Estrogen Deficiency and Cellular Senescence in the Pathogenesis of Osteoporosis: Evidence in Young Adult Mice and Older Humans
Aging Cell 2022
Open access · CC-BY
<scp>TNF</scp>‐α/<scp>IFN</scp>‐γ synergy amplifies senescence‐associated inflammation and <scp>SARS‐CoV</scp>‐2 receptor expression via hyper‐activated <scp>JAK</scp>/<scp>STAT1</scp>
Cells 2023
Open access · CC-BY
Senescent Cells: A Therapeutic Target in Cardiovascular Diseases
Journal of the American Society of Nephrology 2021
Preprint · OA
Progressive Cellular Senescence Mediates Renal Dysfunction in Ischemic Nephropathy
Nature Medicine 2024
Preprint · OA
Effects of intermittent senolytic therapy on bone metabolism in postmenopausal women: a phase 2 randomized controlled trial
Mechanisms of Ageing and Development 2021
Open access · CC-BY
Strategies for late phase preclinical and early clinical trials of senolytics
EBioMedicine 2022
Open access · OA
Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans
Aging 2021
Open access · CC-BY