Index

32 accidental hypothermia 235-6 acetylcholine metabolism 100 acetylcholinesterase inhibitors (AChEI) 87, 98, 100-3, 106, 200 ACS, see acute coronary syndrome; anterior circulation stroke actinic keratosis 258, 265 Action in Diabetes and Vascular Disease: Preterax and DiamicroN Controlled Evaluation (ADVANCE trial) 232 Action to Control Cardiovascular Risk in Diabetes (ACCORD trial) 232 activities of daily living (ADL) 6, 15, 49, 57, 92, 96, 108, 291 activity limitations 23, 58 acute abdomen 206-7 acute ascending inflammatory demyelinating polyradiculoneuropathy (AIDP) 86, 87 acute central vertigo 154 acute cholecystitis 197, 206 acute coronary syndrome (ACS) 161, 162, 206, 281 acute exacerbation of COPD 184-5 acute heart failure 166-7 acute inflammation 47, 139 acute kidney injury (AKI) 49, 65, 66, 71, 146, 180, 181, 205, 206, 214, 215 after surgery 72 acute lymphoblastic leukaemia (ALL) 212, 245 acute myeloid leukaemia (AML) 244, 245 Addison's disease 134, 141, 149, 207, 234, 242, 265 adeno-associated virus (AAV) 81 ADL, see activities of daily living adrenal disease 234 adult safeguarding 284 advance care planning (ACP) 123, 292-3 advance decision to refuse treatment (ADRT) 292 advanced glycation end products (AGE) 47 adverse drug reactions 61, 63 aerobic metabolism 46 age-associated memory impairment 92 age discrimination 280-1 ageing 48 cell 44 characteristics altered intercellular communication 47 cell senescence(definition) 46 chronic inflammation 47 deregulated nutrient sensing 45 disabled macroautophagy 47 dysbiosis 47 epigenetics 44-5 genomic instability 44 hallmarks of ageing 44-7 loss of proteostasis(definition) 45 mitochondrial dysfunction(definition) 46 pillars of ageing 44 SASP 46 stem-cell exhaustion 46-7 telomere(definition) attrition 44 defined 40 effects of disease 44 effects of environment and lifestyle 43 genes, causing in humans 42 genetics and lifespan, in humans 42 genetic theories 42-3 microbiome 44 process 41-2 psychosocial theories of 43-4 reliability models 40-1 scenarios 40 stochastic events 43 tissues 48 age-related macular degeneration (AMD) 269 dry (non-exudative) AMD 270 wet (exudative) AMD 270 risk factors, for AMD 269-70 age-sex gap 7 aids to help with daily activities 57 airflow obstruction 184-5 alcohol abuse 85, 127, 207 alcohol-acid-fast bacilli (AAFB) 184 alcoholic dementia 30 alcoholic liver disease (ALD) 196, 249 alkaline phosphatase (ALP) 133, 134, 137, 196, 197, 207, 220, 263, 273 alkylating agents 246, 251 ALL, see acute lymphoblastic leukaemia alpha-glucosidase inhibitor 233 alpha Klotho 46 alpha-synuclein in Lewy bodies 77, 78 seeding amplification assay (Syn-SAA) 79 altered intercellular communication 44, 47 altered response to disease 51 alveolar proteinosis 188 Alzheimer's disease (AD) 2, 30, 47, 79, 83, 89