Telomere attrition

The Hallmarks of Aging

This 2013 Cell review identifies nine candidate hallmarks driving mammalian aging, providing a conceptual framework for understanding the aging process.

Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): Initial Reliability and Validity Data

This 1997 study evaluates the initial reliability and validity of the K-SADS-PL for diagnosing affective and psychotic disorders in school-aged youth.

A map of human genome variation from population-scale sequencing

The 1000 Genomes Project aims to provide a deep characterization of human genome sequence variation as a foundation for investigating the relationship between genotype and phenotype. Here we present results of the pilot phase of the project...

2021 ESC Guidelines on cardiovascular disease prevention in clinical practice

The ESC Guidelines represent the views of the ESC and were produced after careful consideration of the scientific and medical knowledge and the evidence available at the time of their publication. The ESC is not responsible in the event of...

Hallmarks of aging: An expanding universe

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

Normal human cells undergo a finite number of cell divisions and ultimately enter a nondividing state called replicative senescence. It has been proposed that telomere shortening is the molecular clock that triggers senescence. To test this...

Successful Aging

Examines the psychological, social, and biological factors contributing to successful aging and maintenance of well-being in later life. (132 chars)

Prediction of Cardiovascular Events and All-Cause Mortality With Arterial Stiffness

Sarcopenia

Successful Aging

Substantial increases in the relative and absolute number of older persons in our society pose a challenge for biology, social and behavioral science, and medicine. Successful aging is multidimensional, encompassing the avoidance of disease...

Shelterin: the protein complex that shapes and safeguards human telomeres

Added by telomerase, arrays of TTAGGG repeats specify the ends of human chromosomes. A complex formed by six telomere-specific proteins associates with this sequence and protects chromosome ends. By analogy to other chromosomal protein comp...

Accelerated telomere shortening in response to life stress

Numerous studies demonstrate links between chronic stress and indices of poor health, including risk factors for cardiovascular disease and poorer immune function. Nevertheless, the exact mechanisms of how stress gets "under the skin" remai...