Hallmark of aging · H06
Deregulated nutrient-sensing
Dysregulated mTOR, AMPK, IGF-1 signaling.
- Works
- 2,724
- Most cited
- 19,743
Most-cited works
Older Adults' Reasons for Using Technology while Aging in Place
BACKGROUND: Most older adults prefer to age in place, and supporting older adults to remain in their own homes and communities is also favored by policy makers. Technology can play a role in staying independent, active and healthy. However,...
The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
The National Institute on Aging and the Alzheimer's Association charged a workgroup with the task of revising the 1984 criteria for Alzheimer's disease (AD) dementia. The workgroup sought to ensure that the revised criteria would be flexibl...
Engineering precision nanoparticles for drug delivery
Systematic review of the health benefits of physical activity and fitness in school-aged children and youth
BACKGROUND: The purpose was to: 1) perform a systematic review of studies examining the relation between physical activity, fitness, and health in school-aged children and youth, and 2) make recommendations based on the findings. METHODS: T...
AMPK: a nutrient and energy sensor that maintains energy homeostasis
Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement
There is growing interest in the possible health threat posed by endocrine-disrupting chemicals (EDCs), which are substances in our environment, food, and consumer products that interfere with hormone biosynthesis, metabolism, or action res...
INTCAL98 Radiocarbon Age Calibration, 24,000–0 cal BP
The focus of this paper is the conversion of radiocarbon ages to calibrated (cal) ages for the interval 24,000–0 cal BP (Before Present, 0 cal BP = AD 1950), based upon a sample set of dendrochronologically dated tree rings, uranium-thorium...
Resveratrol improves health and survival of mice on a high-calorie diet
Evidence Based Physical Activity for School-age Youth
Upstream and downstream of mTOR
The evolutionarily conserved checkpoint protein kinase, TOR (target of rapamycin), has emerged as a major effector of cell growth and proliferation via the regulation of protein synthesis. Work in the last decade clearly demonstrates that T...