Deregulated nutrient-sensing

Older Adults' Reasons for Using Technology while Aging in Place

BACKGROUND: Most older adults prefer to age in place, and supporting older adults to remain in their own homes and communities is also favored by policy makers. Technology can play a role in staying independent, active and healthy. However,...

The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

The National Institute on Aging and the Alzheimer's Association charged a workgroup with the task of revising the 1984 criteria for Alzheimer's disease (AD) dementia. The workgroup sought to ensure that the revised criteria would be flexibl...

mTOR Signaling in Growth Control and Disease

This 2012 review in Cell examines the role of mTOR signaling pathways in the regulation of cellular growth and the progression of human disease.

Engineering precision nanoparticles for drug delivery

Systematic review of the health benefits of physical activity and fitness in school-aged children and youth

BACKGROUND: The purpose was to: 1) perform a systematic review of studies examining the relation between physical activity, fitness, and health in school-aged children and youth, and 2) make recommendations based on the findings. METHODS: T...

AMPK: a nutrient and energy sensor that maintains energy homeostasis

This review from Nature Reviews Molecular Cell Biology 2012 examines the role of AMPK as a sensor of nutrient and energy status in maintaining homeostasis.

Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement

There is growing interest in the possible health threat posed by endocrine-disrupting chemicals (EDCs), which are substances in our environment, food, and consumer products that interfere with hormone biosynthesis, metabolism, or action res...

INTCAL98 Radiocarbon Age Calibration, 24,000–0 cal BP

The focus of this paper is the conversion of radiocarbon ages to calibrated (cal) ages for the interval 24,000–0 cal BP (Before Present, 0 cal BP = AD 1950), based upon a sample set of dendrochronologically dated tree rings, uranium-thorium...

Resveratrol improves health and survival of mice on a high-calorie diet

This 2006 study published in Nature examines the effects of resveratrol supplementation on the health and survival of mice fed a high-calorie diet.

Upstream and downstream of mTOR

The evolutionarily conserved checkpoint protein kinase, TOR (target of rapamycin), has emerged as a major effector of cell growth and proliferation via the regulation of protein synthesis. Work in the last decade clearly demonstrates that T...

Evidence Based Physical Activity for School-age Youth

Review the evidence-based physical activity guidelines for school-aged youth to support optimal health and development published in The Journal of Pediatrics (2

Papillomaviruses and cancer: from basic studies to clinical application

This 2002 Nature Reviews Cancer article examines the mechanisms of papillomavirus-induced carcinogenesis and their translation into clinical applications.