Disabled macroautophagy

Two new Later Stone Age sites from the Final Pleistocene in the Falémé Valley, eastern Senegal

30 pages, 8 figures, 1 table, supporting information https://doi.org/10.1371/journal.pone.0308461.-- Data Availability: The data underlying the results presented in the study are available through ONC’s Oceans 3.0 data management system (ht...

IntCal13 and Marine13 Radiocarbon Age Calibration Curves 0–50,000 Years cal BP

The IntCal09 and Marine09 radiocarbon calibration curves have been revised utilizing newly available and updated data sets from 14 C measurements on tree rings, plant macrofossils, speleothems, corals, and foraminifera. The calibration curv...

Extended ¹⁴C Data Base and Revised CALIB 3.0 ¹⁴C Age Calibration Program

The age calibration program, CALIB (Stuiver & Reimer 1986), first made available in 1986 and subsequently modified in 1987 (revision 2.0 and 2.1), has been amended anew. The 1993 program (revision 3.0) incorporates further refinements a...

Epidemiology and causes of preterm birth

Autophagy fights disease through cellular self-digestion

The Information Age: Economy, Society and Culture

Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy

BACKGROUND/AIMS: the anti-vascular endothelial growth factors (VEGF), Aflibercept and Ranibizumab, are used for the treatment of macular degeneration. Here we examined the involvement of nitric oxide (NO), mitochondria function and of apopt...

Plant Polyphenols as Dietary Antioxidants in Human Health and Disease

Polyphenols are secondary metabolites of plants and are generally involved in defense against ultraviolet radiation or aggression by pathogens. In the last decade, there has been much interest in the potential health benefits of dietary pla...

Ferroptosis: molecular mechanisms and health implications

Cell death can be executed through different subroutines. Since the description of ferroptosis as an iron-dependent form of non-apoptotic cell death in 2012, there has been mounting interest in the process and function of ferroptosis. Ferro...

Autophagy: process and function

Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome. Despite its simplicity, recent progress has demonstrated that autophagy plays a wide variety of physiological and pathophysiological ro...

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

Loss-of-function mutations in PINK1 and Parkin cause parkinsonism in humans and mitochondrial dysfunction in model organisms. Parkin is selectively recruited from the cytosol to damaged mitochondria to trigger their autophagy. How Parkin re...