Hallmark of aging · H12
Dysbiosis
Disruption of the microbiome.
- Works
- 418
- Most cited
- 20,431
Most-cited works
Lifetime Prevalence and Age-of-Onset Distributions of DSM-IV Disorders in the National Comorbidity Survey Replication
CONTEXT: Little is known about lifetime prevalence or age of onset of DSM-IV disorders. OBJECTIVE: To estimate lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the recently completed National Comorbidity Survey Repl...
Development of a WHO growth reference for school-aged children and adolescents
OBJECTIVE: To construct growth curves for school-aged children and adolescents that accord with the WHO Child Growth Standards for preschool children and the body mass index (BMI) cut-offs for adults. METHODS: Data from the 1977 National Ce...
Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017
BACKGROUND: Global development goals increasingly rely on country-specific estimates for benchmarking a nation's progress. To meet this need, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 estimated global, regio...
Human gut microbiome viewed across age and geography
Gut microbial communities represent one source of human genetic and metabolic diversity. To examine how gut microbiomes differ among human populations, here we characterize bacterial species in fecal samples from 531 individuals, plus the g...
The genetic legacy of the Quaternary ice ages
The amyloid hypothesis of Alzheimer's disease at 25 years
Despite continuing debate about the amyloid β-protein (or Aβ hypothesis, new lines of evidence from laboratories and clinics worldwide support the concept that an imbalance between production and clearance of Aβ42 and related Aβ peptides is...
Ranibizumab for Neovascular Age-Related Macular Degeneration
BACKGROUND: Ranibizumab--a recombinant, humanized, monoclonal antibody Fab that neutralizes all active forms of vascular endothelial growth factor A--has been evaluated for the treatment of neovascular age-related macular degeneration. METH...
The adolescent brain and age-related behavioral manifestations
Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis
BACKGROUND: Numerous population-based studies of age-related macular degeneration have been reported around the world, with the results of some studies suggesting racial or ethnic differences in disease prevalence. Integrating these resourc...
The second machine age: work, progress, and prosperity in a time of brilliant technologies
A New York Times Bestseller A revolution is under way. In recent years, Googles autonomous cars have logged thousands of miles on American highways and IBMs Watson trounced the best human Jeopardy! players. Digital technologieswith hardware...
Variations in the Earth's Orbit: Pacemaker of the Ice Ages
1) Three indices of global climate have been monitored in the record of the past 450,000 years in Southern Hemisphere ocean-floor sediments. 2) Over the frequency range 10(-4) to 10(-5) cycle per year, climatic variance of these records is...