Loss of proteostasis

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

A systematic GBD 2010 analysis quantifying global and regional mortality for 235 causes across 20 age groups in 1990 and 2010. Published in The Lancet.

The IntCal20 Northern Hemisphere Radiocarbon Age Calibration Curve (0–55 cal kBP)

ABSTRACT Radiocarbon ( 14 C) ages cannot provide absolutely dated chronologies for archaeological or paleoenvironmental studies directly but must be converted to calendar age equivalents using a calibration curve compensating for fluctuatio...

SCENIC: single-cell regulatory network inference and clustering

SCENIC is a computational method for simultaneous gene regulatory network inference and cell clustering from single-cell RNA sequencing data. Nature Methods.

Alzheimer's disease

Dictionary learning for integrative, multimodal and scalable single-cell analysis

This study in Nature Biotechnology 2023 presents a dictionary learning framework designed for integrative and scalable analysis of multimodal single-cell data.

Coming of age: ten years of next-generation sequencing technologies

This review in Nature Reviews Genetics from 2016 examines the technological developments and maturation of next-generation sequencing over ten years.

Head and neck squamous cell carcinoma

Most head and neck cancers are derived from the mucosal epithelium in the oral cavity, pharynx and larynx and are known collectively as head and neck squamous cell carcinoma (HNSCC). Oral cavity and larynx cancers are generally associated w...

Glutathione Metabolism and Its Implications for Health

This 2004 article in the Journal of Nutrition examines glutathione metabolism and its physiological implications for human health.

Intcal04 Terrestrial Radiocarbon Age Calibration, 0–26 Cal Kyr BP

A new calibration curve for the conversion of radiocarbon ages to calibrated (cal) ages has been constructed and internationally ratified to replace IntCal98, which extended from 0–24 cal kyr BP (Before Present, 0 cal BP = AD 1950). The new...

Parkinson's disease

This Lancet review examines the epidemiology, pathophysiology, diagnosis, and current management strategies for Parkinson's disease.

Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

Mutations in the genes for amyloid precursor protein (APP) and presenilins (PS1, PS2) increase production of beta-amyloid 42 (Abeta42) and cause familial Alzheimer's disease (FAD). Transgenic mice that express FAD mutant APP and PS1 overpro...

The golden age: gold nanoparticles for biomedicine

Gold nanoparticles have been used in biomedical applications since their first colloidal syntheses more than three centuries ago. However, over the past two decades, their beautiful colors and unique electronic properties have also attracte...