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Caenorhabditis Intervention Testing Program: the putative mTOR inhibitors Cinnarizine and Meclizine do not extend lifespan in C. elegans

Erik Johnson, Christine A. Sedore, Anna L Coleman-Hulbert, Brian Onken, Madhuri Achanta, Yuhua Song, Gino A. Cortopassi, Gordon J. Lithgow, Monica Driscoll, Patrick C. Phillips

PubMed Central · 2026

Abstract

lifespan at lower doses, and that both compounds exert a toxic effect at higher doses, significantly shortening lifespan.

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Provenance

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OpenAlex
DOI
10.17912/micropub.biology.002198
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2026-10-30 MST

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APA
Johnson, E., Sedore, C.A., Coleman-Hulbert, A.L., Onken, B., Achanta, M., Song, Y., Cortopassi, G.A., Lithgow, G.J., Driscoll, M., &amp; Phillips, P.C. (2026). Caenorhabditis Intervention Testing Program: the putative mTOR inhibitors Cinnarizine and Meclizine do not extend lifespan in C. elegans. <em>PubMed Central</em>. https://doi.org/10.17912/micropub.biology.002198
Vancouver
Johnson E, Sedore CA, Coleman-Hulbert AL, Onken B, Achanta M, Song Y, et al. Caenorhabditis Intervention Testing Program: the putative mTOR inhibitors Cinnarizine and Meclizine do not extend lifespan in C. elegans. PubMed Central. 2026. doi:10.17912/micropub.biology.002198.
BibTeX
@unpublished{erik2026Caenor, title = {Caenorhabditis Intervention Testing Program: the putative mTOR inhibitors Cinnarizine and Meclizine do not extend lifespan in C. elegans}, author = {Erik Johnson and Christine A. Sedore and Anna L Coleman-Hulbert and Brian Onken and Madhuri Achanta and Yuhua Song and Gino A. Cortopassi and Gordon J. Lithgow and Monica Driscoll and Patrick C. Phillips}, journal = {PubMed Central}, year = {2026}, doi = {10.17912/micropub.biology.002198}, }

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