<i>Caenorhabditis</i> Intervention Testing Program: the putative mTOR inhibitors Cinnarizine and Meclizine do not extend lifespan in <i>C. elegans</i>.

The mechanistic target of mTOR(definition)-inhibiting drug studied for extending healthspan and lifespan." style="text-decoration:underline dotted; text-underline-offset:2px; cursor:help;">rapamycin(definition) (mTOR), a protein kinase and master cell regulator, is one of the most validated longevity drug targets: mTOR inhibition by compounds like rapamycin has been shown to significantly extend lifespan in numerous model organisms. Here, we tested whether the novel putative mTOR-inhibiting compounds cinnarizine and meclizine could likewise increase lifespan in the nematode <i>C. elegans</i> , following standardized protocols from the <i>Caenorhabditis</i> Intervention Testing Program (CITP). Our results indicate that cinnarizine and meclizine have no effect on <i>C. elegans</i> lifespan at lower doses, and that both compounds exert a toxic effect at higher doses, significantly shortening lifespan.