Author
Gordon J. Lithgow
- Indexed works
- 32
- Total citations
- 7,230
- Active years
- 16
Collaborators
Works in the record
Cell 2014
Open access · OA
Geroscience: Linking Aging to Chronic Disease
Nature 2019
Open access · OA
From discoveries in ageing research to therapeutics for healthy ageing
Aging Cell 2015
Open access · CC-BY
Long live <scp>FOXO</scp> : unraveling the role of <scp>FOXO</scp> proteins in aging and longevity
Aging 2009
Open access · CC-BY
MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8
Nature 2011
Preprint · OA
Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan
Aging Cell 2003
Open access · OA
Lifespan extension in C. elegans by a molecular chaperone dependent upon insulin‐like signals
Aging Cell 2011
Open access · CC0
Proteomic analysis of age‐dependent changes in protein solubility identifies genes that modulate lifespan
Aging Cell 2019
Open access · CC-BY
Acarbose improves health and lifespan in aging HET3 mice
Journal of Neuroscience 2015
Open access · CC-BY
Mitochondrial Quality Control via the PGC1α-TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin
Aging Cell 2003
Open access · OA
Oxidative stress in Caenorhabditis elegans : protective effects of superoxide dismutase/catalase mimetics
Journal of the American Geriatrics Society 2021
Preprint · OA
Moving geroscience from the bench to clinical care and health policy
Aging Cell 2006
Open access · OA
The nuclear hormone receptor DAF‐12 has opposing effects on Caenorhabditis elegans lifespan and regulates genes repressed in multiple long‐lived worms
Aging 2014
Open access · CC-BY
Iron promotes protein insolubility and aging in C. elegans
PLoS ONE 2016
Open access · CC-BY
Zinc Levels Modulate Lifespan through Multiple Longevity Pathways in Caenorhabditis elegans
Nature Aging 2023
Open access · OA
A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan
Aging Cell 2021
Open access · CC-BY
Metformin treatment of diverse Caenorhabditis species reveals the importance of genetic background in longevity and healthspan extension outcomes
bioRxiv (Cold Spring Harbor Laboratory) 2019
Preprint · OA
Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice
Cell chemical biology 2024
Open access · CC-BY
β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain
Aging Cell 2012
Open access · OA
Pharmacological maintenance of protein homeostasis could postpone age‐related disease
PubMed Central 2022
Preprint · CC-BY
Genetic diversity estimates for the Caenorhabditis Intervention Testing Program screening panel
Aging 2024
Open access · CC-BY
The coupling between healthspan and lifespan in Caenorhabditis depends on complex interactions between compound intervention and genetic background
JBMR Plus 2021
Open access · CC-BY
Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs
GeroScience 2025
Open access · CC0
NIA Caenorhabditis Intervention Testing Program: identification of robust and reproducible pharmacological interventions that promote longevity across experimentally accessible, genetically diverse populations
PubMed Central 2020
Preprint · CC-BY
Caenorhabditis Intervention Testing Program: the creatine analog β-guanidinopropionic acid does not extend lifespan in nematodes
GeroScience 2024
Open access · CC-BY
Amyloid β accelerates age-related proteome-wide protein insolubility
bioRxiv (Cold Spring Harbor Laboratory) 2022
Preprint · CC-BY
The coupling between healthspan and lifespan in Caenorhabditis depends on complex interactions between compound intervention and genetic background
bioRxiv (Cold Spring Harbor Laboratory) 2026
Preprint · CC-BY
Shifts in protein aggregate stability define proteostasis decline in the aging human brain
eLife 2024
Preprint · CC-BY
Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically diverse Caenorhabditis nematodes
eLife 2025
Open access · CC-BY
Computer prediction and genetic analysis identifies retinoic acid modulation as a driver of conserved longevity pathways in genetically diverse Caenorhabditis nematodes
bioRxiv (Cold Spring Harbor Laboratory) 2023
Preprint · CC-BY
Amyloid β accelerates age-related proteome-wide protein insolubility
Innovation in Aging 2022
Open access · CC-BY
ANTI-AGING COMPOUNDS METFORMIN AND THIOFLAVIN T CAN ACT ON GENETICALLY DIVERSE, PROTEOSTASIS-COMPROMISED STRAINS
PubMed Central 2026
Preprint · CC-BY