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SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3

Utkarsh Tripathi, Rayhane Nchioua, Larissa Prata, Yi Zhu, Erin O. Wissler Gerdes, Nino Giorgadze, Tamar Pirtskhalava, Erik Parker, Ailing Xue, Jair Machado Espíndola‐Netto, Steffen Stenger, Paul D. Robbins, Laura J. Niedernhofer, Stephanie Dickinson, David B. Allison

Aging · 2021 · ▲ 88 citations

Abstract

senescent cell burden was higher in patients who died from acute SARS-CoV-2 infection than other causes. Our results suggest that induction of cellular senescence(definition) and SASP amplification through TLR-3 contribute to SARS-CoV-2 morbidity, indicating that clinical trials of senolytics(definition) and/or SASP/TLR-3 inhibitors for alleviating acute and long-term SARS-CoV-2 sequelae are warranted.

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Provenance

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OpenAlex
DOI
10.18632/aging.203560
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2026-06-15 MST

Cite this

APA
Tripathi, U., Nchioua, R., Prata, L., Zhu, Y., Gerdes, E.O.W., Giorgadze, N., Pirtskhalava, T., Parker, E., Xue, A., Espíndola‐Netto, J.M., Stenger, S., Robbins, P.D., Niedernhofer, L.J., Dickinson, S., Allison, D.B., Kirchhoff, F., Sparrer, K.M.J., Tchkonia, T., &amp; Kirkland, J.L. (2021). SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3. <em>Aging</em>. https://doi.org/10.18632/aging.203560
Vancouver
Tripathi U, Nchioua R, Prata L, Zhu Y, Gerdes EOW, Giorgadze N, et al. SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3. Aging. 2021. doi:10.18632/aging.203560.
BibTeX
@article{utkarsh2021SARSCo, title = {SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3}, author = {Utkarsh Tripathi and Rayhane Nchioua and Larissa Prata and Yi Zhu and Erin O. Wissler Gerdes and Nino Giorgadze and Tamar Pirtskhalava and Erik Parker and Ailing Xue and Jair Machado Espíndola‐Netto and Steffen Stenger and Paul D. Robbins and Laura J. Niedernhofer and Stephanie Dickinson and David B. Allison and Frank Kirchhoff and Konstantin M. J. Sparrer and Tamar Tchkonia and James L. Kirkland}, journal = {Aging}, year = {2021}, doi = {10.18632/aging.203560}, }

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