Author
Laura J. Niedernhofer
- Indexed works
- 47
- Total citations
- 13,895
- Active years
- 13
Collaborators
Works in the record
Cell 2019
Open access · OA
Cellular Senescence: Defining a Path Forward
Aging Cell 2015
Open access · CC-BY
Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors
EBioMedicine 2018
Open access · CC-BY
Fisetin is a senotherapeutic that extends health and lifespan
Nature Communications 2022
Open access · CC-BY
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
Aging 2017
Open access · CC-BY
New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463
Nature Communications 2017
Open access · CC-BY
Identification of HSP90 inhibitors as a novel class of senolytics
Nature 2006
Citation only
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
Journal of Clinical Investigation 2022
Open access · CC-BY
Cellular senescence: a key therapeutic target in aging and diseases
FEBS Journal 2022
Open access · OA
Targeting cellular senescence with senotherapeutics: senolytics and senomorphics
JNCI Journal of the National Cancer Institute 2021
Open access · CC-BY
Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy
Aging Cell 2020
Open access · CC-BY
Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice
The Annual Review of Pharmacology and Toxicology 2020
Open access · OA
Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span
Cell 2024
Open access · CC-BY
Guidelines for minimal information on cellular senescence experimentation in vivo
Annual Review of Biochemistry 2018
Open access · OA
Nuclear Genomic Instability and Aging
The Journals of Gerontology Series A 2021
Preprint · OA
Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice
Chemical Research in Toxicology 2016
Citation only
Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage
Nature Reviews Drug Discovery 2018
Open access · OA
Senotherapeutics for healthy ageing
Aging Cell 2019
Open access · CC-BY
Systemic clearance of <i>p16<sup>INK4a</sup></i>‐positive senescent cells mitigates age‐associated intervertebral disc degeneration
Nature reviews. Immunology 2022
Open access · OA
COVID-19 and cellular senescence
Journal of Clinical Investigation 2022
Open access · CC-BY
Epigenetics, DNA damage, and aging
Immunity & Ageing 2023
Open access · CC-BY
Aging and chronic inflammation: highlights from a multidisciplinary workshop
Nature Aging 2023
Preprint · OA
Spatial mapping of cellular senescence: emerging challenges and opportunities
Journal of Bone and Mineral Research 2012
Open access · OA
DNA damage drives accelerated bone aging via an NF-<b>κ</b>B–dependent mechanism
Endocrinology 2021
Open access · OA
Role of Cellular Senescence in Type II Diabetes
Aging Cell 2017
Open access · CC-BY
Circulating levels of monocyte chemoattractant protein‐1 as a potential measure of biological age in mice and frailty in humans
Aging 2020
Preprint · CC-BY
ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging
Mutation research. Fundamental and molecular mechanisms of mutagenesis 2006
Citation only
Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice
Aging 2021
Open access · CC-BY
SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3
Aging Cell 2021
Open access · CC-BY
Novel small molecule inhibition of IKK/NF‐κB activation reduces markers of senescence and improves healthspan in mouse models of aging
GeroScience 2020
Open access · OA
Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues
bioRxiv (Cold Spring Harbor Laboratory) 2021
Preprint · OA
A New Gene Set Identifies Senescent Cells and Predicts Senescence-Associated Pathways Across Tissues
Ageing Research Reviews 2016
Citation only
Molecular pathology endpoints useful for aging studies
Annals of the New York Academy of Sciences 2021
Preprint · OA
Extending human healthspan and longevity: a symposium report
Journal of the American Geriatrics Society 2021
Open access · CC-BY
Fisetin for <scp>COVID</scp> ‐19 in skilled nursing facilities: Senolytic trials in the <scp>COVID</scp> era
Molecular Therapy — Methods & Clinical Development 2019
Open access · CC-BY
Rapamycin Rescues Age-Related Changes in Muscle-Derived Stem/Progenitor Cells from Progeroid Mice
Mechanisms of Ageing and Development 2019
Citation only
Oxidative stress-induced senescence markedly increases disc cell bioenergetics
Journal of Orthopaedic Research® 2016
Open access · CC-BY
mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging
Cancers 2021
Open access · CC-BY
The Role of Senescent Cells in Acquired Drug Resistance and Secondary Cancer in BRAFi-Treated Melanoma
Journal of Visualized Experiments 2019
Citation only
SA-&#946;-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
bioRxiv (Cold Spring Harbor Laboratory) 2023
Preprint · CC-BY
Distinct secretomes in p16- and p21- positive senescent cells across tissues
Aging Cell 2024
Open access · CC-BY
Clinical validation of <scp>C<sub>12</sub>FDG</scp> as a marker associated with senescence and osteoarthritic phenotypes
Cell Metabolism 2025
Preprint · OA
Endothelial senescent-cell-specific clearance alleviates metabolic dysfunction in obese mice
Aging Cell 2017
Open access · CC-BY
Advances in Therapeutic Approaches to Extend Healthspan: a perspective from the 2<sup>nd</sup> Scripps Symposium on the Biology of Aging
Trials 2024
Open access · CC-BY
Senolytics To slOw Progression of Sepsis (STOP-Sepsis) in elderly patients: Study protocol for a multicenter, randomized, adaptive allocation clinical trial
Aging Cell 2025
Open access · CC-BY
Identification of Senomorphic <scp>miRNAs</scp> in Embryonic Progenitor and Adult Stem Cell‐Derived Extracellular Vesicles
Aging Pathobiology and Therapeutics 2019
Open access · CC-BY
The rationale for testing drug combinations in aging intervention studies
bioRxiv (Cold Spring Harbor Laboratory) 2023
Preprint · CC-BY