Author
Laura J. Niedernhofer
- Indexed works
- 49
- Total citations
- 14,386
- Active years
- 13
Collaborators
Works in the record
Cell 2019
Open access · OA
Cellular Senescence: Defining a Path Forward
Aging Cell 2015
Open access · CC-BY
Identification of a novel senolytic agent, navitoclax, targeting the Bcl‐2 family of anti‐apoptotic factors
Nature Communications 2022
Open access · CC-BY
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
EBioMedicine 2018
Open access · CC-BY
Fisetin is a senotherapeutic that extends health and lifespan
Aging 2017
Open access · CC-BY
New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463
Nature Communications 2017
Open access · CC-BY
Identification of HSP90 inhibitors as a novel class of senolytics
Nature 2006
Citation only
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
Journal of Clinical Investigation 2022
Open access · CC-BY
Cellular senescence: a key therapeutic target in aging and diseases
FEBS Journal 2022
Citation only
Targeting cellular senescence with senotherapeutics: senolytics and senomorphics
JNCI Journal of the National Cancer Institute 2021
Open access · CC-BY
Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy
Cell 2024
Open access · CC-BY
Guidelines for minimal information on cellular senescence experimentation in vivo
Aging Cell 2020
Open access · CC-BY
Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice
The Annual Review of Pharmacology and Toxicology 2020
Open access · OA
Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span
Annual Review of Biochemistry 2018
Open access · OA
Nuclear Genomic Instability and Aging
The Journals of Gerontology Series A 2021
Preprint · OA
Senolytic Combination of Dasatinib and Quercetin Alleviates Intestinal Senescence and Inflammation and Modulates the Gut Microbiome in Aged Mice
Chemical Research in Toxicology 2016
Preprint · OA
Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage
Nature Reviews Drug Discovery 2018
Citation only
Senotherapeutics for healthy ageing
Aging Cell 2019
Open access · CC-BY
Systemic clearance of p16 INK4a ‐positive senescent cells mitigates age‐associated intervertebral disc degeneration
Nature reviews. Immunology 2022
Open access · OA
COVID-19 and cellular senescence
Journal of Clinical Investigation 2022
Open access · CC-BY
Epigenetics, DNA damage, and aging
Immunity & Ageing 2023
Open access · CC-BY
Aging and chronic inflammation: highlights from a multidisciplinary workshop
Nature Aging 2023
Preprint · OA
Spatial mapping of cellular senescence: emerging challenges and opportunities
Endocrinology 2021
Open access · OA
Role of Cellular Senescence in Type II Diabetes
Journal of Bone and Mineral Research 2012
Open access · OA
DNA damage drives accelerated bone aging via an NF-<b>κ</b>B–dependent mechanism
Aging 2020
Preprint · CC-BY
ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging
Aging Cell 2017
Open access · CC-BY
Circulating levels of monocyte chemoattractant protein‐1 as a potential measure of biological age in mice and frailty in humans
Mutation research. Fundamental and molecular mechanisms of mutagenesis 2006
Citation only
Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice
Cell Cycle 2018
Open access · OA
Hsp90 inhibitors as senolytic drugs to extend healthy aging
Aging 2021
Open access · CC-BY
SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3
Aging Cell 2021
Open access · CC-BY
Novel small molecule inhibition of IKK/NF‐κB activation reduces markers of senescence and improves healthspan in mouse models of aging
GeroScience 2020
Open access · OA
Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues
Ageing Research Reviews 2016
Preprint · OA
Molecular pathology endpoints useful for aging studies
bioRxiv (Cold Spring Harbor Laboratory) 2021
Preprint · OA
A New Gene Set Identifies Senescent Cells and Predicts Senescence-Associated Pathways Across Tissues
Annals of the New York Academy of Sciences 2021
Preprint · OA
Extending human healthspan and longevity: a symposium report
Journal of the American Geriatrics Society 2021
Open access · CC-BY
Fisetin for COVID ‐19 in skilled nursing facilities: Senolytic trials in the COVID era
Molecular Therapy — Methods & Clinical Development 2019
Open access · CC-BY
Rapamycin Rescues Age-Related Changes in Muscle-Derived Stem/Progenitor Cells from Progeroid Mice
Mechanisms of Ageing and Development 2019
Citation only
Oxidative stress-induced senescence markedly increases disc cell bioenergetics
Journal of Orthopaedic Research® 2016
Open access · CC-BY
mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging
Journal of Visualized Experiments 2019
Citation only
SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
Cancers 2021
Open access · CC-BY
The Role of Senescent Cells in Acquired Drug Resistance and Secondary Cancer in BRAFi-Treated Melanoma
bioRxiv (Cold Spring Harbor Laboratory) 2023
Preprint · CC-BY
Distinct secretomes in p16- and p21- positive senescent cells across tissues
Aging Cell 2024
Open access · CC-BY
Clinical validation of C 12 FDG as a marker associated with senescence and osteoarthritic phenotypes
Cell Metabolism 2025
Preprint · OA
Endothelial senescent-cell-specific clearance alleviates metabolic dysfunction in obese mice
Trials 2024
Open access · CC-BY
Senolytics To slOw Progression of Sepsis (STOP-Sepsis) in elderly patients: Study protocol for a multicenter, randomized, adaptive allocation clinical trial
Aging Cell 2017
Open access · CC-BY
Advances in Therapeutic Approaches to Extend Healthspan: a perspective from the 2nd Scripps Symposium on the Biology of Aging
Aging Cell 2025
Open access · CC-BY
Identification of Senomorphic <scp>miRNAs</scp> in Embryonic Progenitor and Adult Stem Cell‐Derived Extracellular Vesicles
Aging Pathobiology and Therapeutics 2019
Open access · CC-BY
The rationale for testing drug combinations in aging intervention studies
bioRxiv (Cold Spring Harbor Laboratory) 2023
Preprint · CC-BY
Longevity-associated SMAD3 non-coding centenarian variant impairs a cell-type specific enhancer to reduce inflammation
bioRxiv (Cold Spring Harbor Laboratory) 2025
Preprint · CC-BY