Open access · CC-BY via OpenAlex

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

Davide D’Amico, Pénélope A. Andreux, Pamela Valdés, Anurag Singh, Chris Rinsch, Johan Auwerx

Trends in Molecular Medicine · 2021 · ▲ 402 citations

Dysbiosis Mitochondrial dysfunction Chronic inflammation Disabled macroautophagy Human Preclinical / animal Review

Abstract

Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate, berries, and nuts. UA was discovered 40 years ago, but only recently has its impact on aging and disease been explored. UA enhances cellular health by increasing mitophagy and mitochondrial function and reducing detrimental inflammation. Several preclinical studies show how UA protects against aging and age-related conditions affecting muscle, brain, joints, and other organs. In humans, benefits of UA supplementation in the muscle are supported by recent clinical trials in elderly people. Here, we review the state of the art of UA's biology and its translational potential as a nutritional intervention in humans.

◌ CITATION ONLY
Full text is not openly licensed for redistribution here. Read it at the source:

Read at source →

Provenance

Source: OpenAlex
DOI: 10.1016/j.molmed.2021.04.009
Canonical: link ↗
Fetched: 2026-08-03 MST

Cite this

APA

D’Amico, D., Andreux, P.A., Valdés, P., Singh, A., Rinsch, C., & Auwerx, J. (2021). Impact of the Natural Compound Urolithin A on Health, Disease, and Aging. <em>Trends in Molecular Medicine</em>. https://doi.org/10.1016/j.molmed.2021.04.009

Vancouver

D’Amico D, Andreux PA, Valdés P, Singh A, Rinsch C, Auwerx J. Impact of the Natural Compound Urolithin A on Health, Disease, and Aging. Trends in Molecular Medicine. 2021. doi:10.1016/j.molmed.2021.04.009.

BibTeX

@article{davide2021Impact, title = {Impact of the Natural Compound Urolithin A on Health, Disease, and Aging}, author = {Davide D’Amico and Pénélope A. Andreux and Pamela Valdés and Anurag Singh and Chris Rinsch and Johan Auwerx}, journal = {Trends in Molecular Medicine}, year = {2021}, doi = {10.1016/j.molmed.2021.04.009}, }