Age-Related Changes in Proportions of Urolithins A, B, and 0

Nowadays, aging is the actual theme above the world. Scientists are working on to prevent aging. In this article, we discuss how Urolithin effects on human body and aging process. Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate, berries, and nuts. Mitochondria play a crucial role in cellular function and are particularly important in aging and decrepit cells by the function of mitophagy. During this process pathological mitochondria are killed, that controls the quality of mitochondrias and proteins. Mitochondrial dysfunction(definition) can trigger cellular responses associated with inflammation and cellular senescence(definition). Urolithins (microbial metabolites) found in various tissues after ellagitannin consumption, has been demonstrated to possess antioxidant and anti-inflammatory effects.