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GENETICS AND EPIGENETICS OF AGING AND LONGEVITY

Ecological genetics · 2013 · ▲ 8 citations

Genomic instability Epigenetic alterations Loss of proteostasis Deregulated nutrient-sensing Cellular senescence Altered intercellular communication Chronic inflammation Disabled macroautophagy Human Review

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Abstract

This review covers the main groups of genes that determine the rate of aging and longevity in model animals and humans. The focus is on genes of insulin/IGF-1, PI3K-, TOR-, MAPK-, NF-kB-, TGF-β-, WNT-signaling pathways, stress resistance genes (chaperones, antioxidant genes, autophagy, proteasomal degradation, DNA repair) and genes of cellular senescence (pRB, p21, p16, p53). The groups of genes that alter their activity during human aging and epigenetic mechanisms of age-related changes are described

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Provenance

Source: OpenAlex
DOI: 10.17816/ecogen1113-11
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Fetched: 2026-10-22 MST

Cite this

APA

Moskalev, A.A. (2013). GENETICS AND EPIGENETICS OF AGING AND LONGEVITY. <em>Ecological genetics</em>. https://doi.org/10.17816/ecogen1113-11

Vancouver

Moskalev AA. GENETICS AND EPIGENETICS OF AGING AND LONGEVITY. Ecological genetics. 2013. doi:10.17816/ecogen1113-11.

BibTeX

@article{aleksey2013GENETI, title = {GENETICS AND EPIGENETICS OF AGING AND LONGEVITY}, author = {Aleksey Aleksandrovich Moskalev}, journal = {Ecological genetics}, year = {2013}, doi = {10.17816/ecogen1113-11}, }