Feasibility Analysis of Mainstream Aging Theories and Intervention

Many aging theories are incorrect, which explains the lack of effective interventions and even the emergence of contradictory results. Here, we first briefly introduce the latest aging theory: the Telomere(definition) DNA and Ribosomal DNA Co-regulation Model for Cell Senescence(definition) (TRCS). We then conduct a critical analysis of several mainstream aging theories and their corresponding interventions. Our findings suggest that key aging theories—including the Epigenetic Theory, the Free Radical Theory, the Mitochondrial Theory, the Somatic Mutation Theory, the Autophagy(definition) Theory, and the Inflammation Theory of Aging—may be fundamentally flawed. This is because interventions derived from these theories—including the elimination of senescent cells and the infusion of young plasma—fail to significantly extend lifespan and, in some instances, have even been reported to accelerate aging.