Hallmark of aging · H09
Stem-cell exhaustion
Decline in regenerative cell pools.
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Most-cited works
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan,...
A Novel Coronavirus from Patients with Pneumonia in China, 2019
In December 2019, a cluster of patients with pneumonia of unknown cause was linked to a seafood wholesale market in Wuhan, China. A previously unknown betacoronavirus was discovered through the use of unbiased sequencing in samples from pat...
Free radicals in biology and medicine
This 1991 review in General Pharmacology examines the role of free radicals in biological systems and their implications for medicine and vascular disease.
UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age
Cathie Sudlow and colleagues describe the UK Biobank, a large population-based prospective study, established to allow investigation of the genetic and non-genetic determinants of the diseases of middle and old age.
STUDIES OF ILLNESS IN THE AGED. THE INDEX OF ADL: A STANDARDIZED MEASURE OF BIOLOGICAL AND PSYCHOSOCIAL FUNCTION.
The Index of ADL was developed to study results of treatment and prognosis in the elderly and chronically ill. Grades of the Index summarize over-all performance in bathing, dressing, going to toilet, transferring, continence, and feeding....
The Ensembl Variant Effect Predictor
The Ensembl Variant Effect Predictor is a powerful toolset for the analysis, annotation, and prioritization of genomic variants in coding and non-coding regions. It provides access to an extensive collection of genomic annotation, with a va...
DNA methylation age of human tissues and cell types
BACKGROUND: It is not yet known whether DNA methylation levels can be used to accurately predict age across a broad spectrum of human tissues and cell types, nor whether the resulting age prediction is a biologically meaningful measure. RES...
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
Read the 2018 recommendations from the Nomenclature Committee on Cell Death for standardized definitions and molecular mechanisms of cell death.
Understanding the tumor immune microenvironment (TIME) for effective therapy
This review in Nature Medicine 2018 examines the tumor immune microenvironment. It discusses how this landscape influences the development of cancer therapy.
Complement Factor H Polymorphism in Age-Related Macular Degeneration
Age-related macular degeneration (AMD) is a major cause of blindness in the elderly. We report a genome-wide screen of 96 cases and 50 controls for polymorphisms associated with AMD. Among 116,204 single-nucleotide polymorphisms genotyped,...
Functions of natural killer cells
This 2008 review in Nature Immunology examines the biological functions of natural killer cells and their role in the immune system.
Some genetic consequences of ice ages, and their role in divergence and speciation
The genetic effects of pleistocene ice ages are approached by deduction from paleoenvironmental information, by induction from the genetic structure of populations and species, and by their combination to infer likely consequences. (1) Rece...