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Mutation of the mouse klotho gene leads to a syndrome resembling ageing.

M Kuro-o, Y Matsumura, H Aizawa, H Kawaguchi, T Suga, T Utsugi, Y Ohyama, M Kurabayashi, T Kaname, E Kume, H Iwasaki, A Iida, T Shiraki-Iida, S Nishikawa, R Nagai

PubMed · 1997 · ▲ 66,557 citations

Stem-cell exhaustion Human Mouse

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Abstract

A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the beta-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.

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Provenance

Source: OpenAlex
DOI: 10.1038/36285
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Fetched: 2026-05-31 MST

Cite this

APA

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., Iwasaki, H., Iida, A., Shiraki-Iida, T., Nishikawa, S., Nagai, R., & Nabeshima, Y.I. (1997). Mutation of the mouse klotho gene leads to a syndrome resembling ageing. <em>PubMed</em>. https://doi.org/10.1038/36285

Vancouver

Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. PubMed. 1997. doi:10.1038/36285.

BibTeX

@unpublished{m1997Mutati, title = {Mutation of the mouse klotho gene leads to a syndrome resembling ageing.}, author = {M Kuro-o and Y Matsumura and H Aizawa and H Kawaguchi and T Suga and T Utsugi and Y Ohyama and M Kurabayashi and T Kaname and E Kume and H Iwasaki and A Iida and T Shiraki-Iida and S Nishikawa and R Nagai and Y I Nabeshima}, journal = {PubMed}, year = {1997}, doi = {10.1038/36285}, }