Metformin

The mechanisms of action of metformin

Metformin is a widely-used drug that results in clear benefits in relation to glucose metabolism and diabetes-related complications. The mechanisms underlying these benefits are complex and still not fully understood. Physiologically, metfo...

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

This 2015 study in Nature investigates the distinct effects of type 2 diabetes and metformin treatment on the composition of the human gut microbiota.

Interventions for treating obesity in children

BACKGROUND: Child and adolescent obesity is increasingly prevalent, and can be associated with significant short- and long-term health consequences. OBJECTIVES: To assess the efficacy of lifestyle, drug and surgical interventions for treati...

Metformin improves healthspan and lifespan in mice

A 2013 study in Nature Communications demonstrates that treating mice with low-dose metformin significantly improves their healthspan and lifespan.

Metformin as a Tool to Target Aging

A Clinical Trial to Maintain Glycemic Control in Youth with Type 2 Diabetes

BACKGROUND: Despite the increasing prevalence of type 2 diabetes in youth, there are few data to guide treatment. We compared the efficacy of three treatment regimens to achieve durable glycemic control in children and adolescents with rece...

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

The biguanide drug metformin is widely prescribed to treat type 2 diabetes and metabolic syndrome, but its mode of action remains uncertain. Metformin also increases lifespan in Caenorhabditis elegans cocultured with Escherichia coli. This...

Epigenetic clock analysis of diet, exercise, education, and lifestyle factors

)-an indicator of fruit and vegetable consumption, whereas intrinsic epigenetic age acceleration (IEAA) is associated with poultry intake (p=0.03) and BMI (p=0.05). Both EEAA and IEAA were also found to relate to indicators of metabolic syn...

Efficacy and Metabolic Effects of Metformin and Troglitazone in Type II Diabetes Mellitus

BACKGROUND: Combination therapy is logical for patients with non-insulin-dependent (type 2) diabetes mellitus, because they often have poor responses to single-drug therapy. We studied the efficacy and physiologic effects of metformin and t...

Benefits of Metformin in Attenuating the Hallmarks of Aging

This 2020 Cell Metabolism review examines the role of metformin in modulating biological pathways associated with the hallmarks of aging.

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status

RATIONALE: The diabetes mellitus drug metformin is under investigation in cardiovascular disease, but the molecular mechanisms underlying possible benefits are poorly understood. OBJECTIVE: Here, we have studied anti-inflammatory effects of...

Metformin: update on mechanisms of action and repurposing potential

This 2023 review in Nature Reviews Endocrinology discusses current understanding of metformin mechanisms and its potential for therapeutic repurposing.