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Metformin as Potential Therapy for High-Grade Glioma

Marek Mazurek, Jakub Litak, Piotr Kamieniak, Bartłomiej Kulesza, Katarzyna Jonak, Jacek Baj, Cezary Grochowski

Cancers · 2020 · ▲ 85 citations

Deregulated nutrient-sensing Metformin Human

Abstract

Metformin (MET), 1,1-dimethylbiguanide hydrochloride, is a biguanide drug used as the first-line medication in the treatment of type 2 diabetes. The recent years have brought many observations showing metformin in its new role. The drug, commonly used in the therapy of diabetes, may also find application in the therapy of a vast variety of tumors. Its effectiveness has been demonstrated in colon, breast, prostate, pancreatic cancer, leukemia, melanoma, lung and endometrial carcinoma, as well as in gliomas. This is especially important in light of the poor options offered to patients in the case of high-grade gliomas, which include glioblastoma (GBM). A thorough understanding of the mechanism of action of metformin can make it possible to discover new drugs that could be used in neoplasm therapy.

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Provenance

Source: OpenAlex
DOI: 10.3390/cancers12010210
Canonical: link ↗
Fetched: 2026-06-01 MST

Cite this

APA

Mazurek, M., Litak, J., Kamieniak, P., Kulesza, B., Jonak, K., Baj, J., & Grochowski, C. (2020). Metformin as Potential Therapy for High-Grade Glioma. <em>Cancers</em>. https://doi.org/10.3390/cancers12010210

Vancouver

Mazurek M, Litak J, Kamieniak P, Kulesza B, Jonak K, Baj J, et al. Metformin as Potential Therapy for High-Grade Glioma. Cancers. 2020. doi:10.3390/cancers12010210.

BibTeX

@article{marek2020Metfor, title = {Metformin as Potential Therapy for High-Grade Glioma}, author = {Marek Mazurek and Jakub Litak and Piotr Kamieniak and Bartłomiej Kulesza and Katarzyna Jonak and Jacek Baj and Cezary Grochowski}, journal = {Cancers}, year = {2020}, doi = {10.3390/cancers12010210}, }