Longevity intervention
Intermittent fasting
- Works
- 1,170
- Most cited
- 2,341
Most-cited works
Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
Skeletal muscle is strongly dependent on oxidative phosphorylation for energy production. Because the insulin resistance of skeletal muscle in type 2 diabetes and obesity entails dysregulation of the oxidation of both carbohydrate and lipid...
Metabolic Syndrome as a Precursor of Cardiovascular Disease and Type 2 Diabetes Mellitus
BACKGROUND: The incidence of cardiovascular disease (CVD), coronary heart disease (CHD), and type 2 diabetes mellitus (T2DM) has not been well defined in persons with the metabolic syndrome (at least 3 of the following: abdominal adiposity,...
Obesity and inflammation: the linking mechanism and the complications
Obesity is the accumulation of abnormal or excessive fat that may interfere with the maintenance of an optimal state of health. The excess of macronutrients in the adipose tissues stimulates them to release inflammatory mediators such as tu...
GLP-1 receptor agonists in the treatment of type 2 diabetes – state-of-the-art
GLP-1 receptor agonists (GLP-1 RAs) with exenatide b.i.d. first approved to treat type 2 diabetes in 2005 have been further developed to yield effective compounds/preparations that have overcome the original problem of rapid elimination (sh...
Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus
Oxidative stress is increased in metabolic syndrome and type 2 diabetes mellitus (T2DM) and this appears to underlie the development of cardiovascular disease, T2DM and diabetic complications. Increased oxidative stress appears to be a dele...
Impact of intermittent fasting on health and disease processes
This review in Ageing Research Reviews examines the impact of intermittent fasting on health and disease processes based on 2016 scientific literature.
Impact of Dietary Polyphenols on Carbohydrate Metabolism
Polyphenols, including flavonoids, phenolic acids, proanthocyanidins and resveratrol, are a large and heterogeneous group of phytochemicals in plant-based foods, such as tea, coffee, wine, cocoa, cereal grains, soy, fruits and berries. Grow...
Body Mass Index, Metabolic Syndrome, and Risk of Type 2 Diabetes or Cardiovascular Disease
CONTEXT: Metabolic risk conferred by adiposity may be due to associated risk factor clustering. OBJECTIVE: The objective of this study was to assess risk for diabetes or cardiovascular disease (CVD) stratified by body mass index (BMI) and t...
Prevention of non-communicable disease in a population in nutrition transition: Tehran Lipid and Glucose Study phase II
BACKGROUND: The Tehran Lipid and Glucose Study (TLGS) is a long term integrated community-based program for prevention of non-communicable disorders (NCD) by development of a healthy lifestyle and reduction of NCD risk factors. The study be...
Effect of 6-Month Calorie Restriction on Biomarkers of Longevity, Metabolic Adaptation, and Oxidative Stress in Overweight Individuals
CONTEXT: Prolonged calorie restriction increases life span in rodents. Whether prolonged calorie restriction affects biomarkers of longevity or markers of oxidative stress, or reduces metabolic rate beyond that expected from reduced metabol...
Caloric restriction improves health and survival of rhesus monkeys
Caloric restriction (CR) without malnutrition extends lifespan and delays the onset of age-related disorders in most species but its impact in nonhuman primates has been controversial. In the late 1980s two parallel studies were initiated t...
A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan
A 2015 study in Cell Metabolism shows that a periodic fasting-mimicking diet promotes multi-system regeneration, cognitive enhancement, and healthspan.