Longevity intervention
Caloric restriction
- Works
- 1,739
- Most cited
- 3,863
Most-cited works
The Free Radical Theory of Aging Matures
The free radical theory of aging, conceived in 1956, has turned 40 and is rapidly attracting the interest of the mainstream of biological research. From its origins in radiation biology, through a decade or so of dormancy and two decades of...
Oxidative Stress, Caloric Restriction, and Aging
Under normal physiological conditions, the use of oxygen by cells of aerobic organisms generates potentially deleterious reactive oxygen metabolites. A chronic state of oxidative stress exists in cells because of an imbalance between prooxi...
Cancer is a Preventable Disease that Requires Major Lifestyle Changes
This year, more than 1 million Americans and more than 10 million people worldwide are expected to be diagnosed with cancer, a disease commonly believed to be preventable. Only 5-10% of all cancer cases can be attributed to genetic defects,...
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established. We report findings of a 20-year...
<i>daf-2</i> , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in <i>Caenorhabditis elegans</i>
A C. elegans neurosecretory signaling system regulates whether animals enter the reproductive life cycle or arrest development at the long-lived dauer diapause stage. daf-2, a key gene in the genetic pathway that mediates this endocrine sig...
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
This 2004 Nature study examines how sirtuin activators mimic the effects of caloric restriction to delay ageing processes in metazoan organisms.
Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
Aging is a gradual and irreversible pathophysiological process. It presents with declines in tissue and cell functions and significant increases in the risks of various aging-related diseases, including neurodegenerative diseases, cardiovas...
Sirtuins in mammals: insights into their biological function
Sirtuins are a conserved family of proteins found in all domains of life. The first known sirtuin, Sir2 (silent information regulator 2) of Saccharomyces cerevisiae, from which the family derives its name, regulates ribosomal DNA recombinat...
Ink4a/Arf expression is a biomarker of aging
The Ink4a/Arf locus encodes 2 tumor suppressor molecules, p16INK4a and Arf, which are principal mediators of cellular senescence. To study the links between senescence and aging in vivo, we examined Ink4a/Arf expression in rodent models of...
Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue
Caloric restriction has been shown to increase longevity in organisms ranging from yeast to mammals. In some organisms, this has been associated with a decreased fat mass and alterations in insulin/insulin-like growth factor 1 (IGF-1) pathw...
Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans
This 2011 study in Cell Metabolism examines the impact of 30 days of resveratrol supplementation on energy metabolism and metabolic profiles in obese humans.