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Sirtuin mediated neuroprotection and its association with autophagy and apoptosis: Studies employing transgenic C. elegans model

Molecular Neurodegeneration · 2013 · ▲ 4 citations

Deregulated nutrient-sensing Disabled macroautophagy Caloric restriction C. elegans Human

Abstract

Background Sirtuins, NAD+-dependent protein deacetylases, are well known for their role in longevity. Aging is the major known risk factor for the onset of Parkinson’s disease (PD). In our previous studies, SIRT1 induction by calorie restriction (CR) diet regimen has been shown to protect against dopaminergic neurodegeneration via sir-2.1 mediated pathway. Taking the studies forward, we endeavoured to understand the role of nicotinamide adenine dinucleotide activated protein deacetylase Sir2p/Sirt1 in calorie restriction mediated prevention of Parkinsonism employing transgenic Caenorhabditis elegans expressing human alpha synuclein.

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Provenance

Source: OpenAlex
DOI: 10.1186/1750-1326-8-s1-p65
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Fetched: 2026-10-23 MST

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APA

Nazir, A., & Jadiya, P. (2013). Sirtuin mediated neuroprotection and its association with autophagy and apoptosis: Studies employing transgenic C. elegans model. <em>Molecular Neurodegeneration</em>. https://doi.org/10.1186/1750-1326-8-s1-p65

Vancouver

Nazir A, Jadiya P. Sirtuin mediated neuroprotection and its association with autophagy and apoptosis: Studies employing transgenic C. elegans model. Molecular Neurodegeneration. 2013. doi:10.1186/1750-1326-8-s1-p65.

BibTeX

@article{aamir2013Sirtui, title = {Sirtuin mediated neuroprotection and its association with autophagy and apoptosis: Studies employing transgenic C. elegans model}, author = {Aamir Nazir and Pooja Jadiya}, journal = {Molecular Neurodegeneration}, year = {2013}, doi = {10.1186/1750-1326-8-s1-p65}, }