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Sex- and age-dependent genetics of longevity in a heterogeneous mouse population

Maroun Bou Sleiman, Suheeta Roy, Arwen W. Gao, Marie C. Sadler, Giacomo von Alvensleben, Hao Li, Śaunak Sen, David E. Harrison, James F. Nelson, Randy Strong, Richard A. Miller, Zoltán Kutalik, Robert W. Williams, Johan Auwerx

Science · 2022 · ▲ 82 citations

Epigenetic alterations C. elegans Human Mouse
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Abstract

DNA variants that modulate life span provide insight into determinants of health, disease, and aging. Through analyses in the UM-HET3 mice of the Interventions Testing Program (ITP), we detected a sex-independent quantitative trait locus (QTL) on chromosome 12 and identified sex-specific QTLs, some of which we detected only in older mice. Similar relations between life history and longevity were uncovered in mice and humans, underscoring the importance of early access to nutrients and early growth. We identified common age- and sex-specific genetic effects on gene expression that we integrated with model organism and human data to create a hypothesis-building interactive resource of prioritized longevity and body weight genes. Finally, we validated Hipk1 , Ddost , Hspg2 , Fgd6 , and Pdk1 as conserved longevity genes using Caenorhabditis elegans life-span experiments.

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Provenance

Source
OpenAlex
DOI
10.1126/science.abo3191
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Fetched
2026-06-29 MST

Cite this

APA
Sleiman, M.B., Roy, S., Gao, A.W., Sadler, M.C., Alvensleben, G.V., Li, H., Sen, �., Harrison, D.E., Nelson, J.F., Strong, R., Miller, R.A., Kutalik, Z., Williams, R.W., &amp; Auwerx, J. (2022). Sex- and age-dependent genetics of longevity in a heterogeneous mouse population. <em>Science</em>. https://doi.org/10.1126/science.abo3191
Vancouver
Sleiman MB, Roy S, Gao AW, Sadler MC, Alvensleben GV, Li H, et al. Sex- and age-dependent genetics of longevity in a heterogeneous mouse population. Science. 2022. doi:10.1126/science.abo3191.
BibTeX
@unpublished{maroun2022Sexand, title = {Sex- and age-dependent genetics of longevity in a heterogeneous mouse population}, author = {Maroun Bou Sleiman and Suheeta Roy and Arwen W. Gao and Marie C. Sadler and Giacomo von Alvensleben and Hao Li and Śaunak Sen and David E. Harrison and James F. Nelson and Randy Strong and Richard A. Miller and Zoltán Kutalik and Robert W. Williams and Johan Auwerx}, journal = {Science}, year = {2022}, doi = {10.1126/science.abo3191}, }

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