Regulation of lifespan through the Insulin/PI3K/TOR/autophagy pathway

Event Abstract Back to Event Regulation of lifespan through the Insulin/PI3K/TOR/autophagy(definition) pathway Gábor Juhász1*, Balazs Érdi1, Miklós Sass1 and Thomas P. Neufeld1 1 Eotvos Lorand University, Department of Anatomy, Cell and Developmental Biology, Hungary Caloric restriction(definition) is a well-known practice to extend lifespan in a variety of model organisms. Reduced nutrient intake decreases growth signaling such as the Insulin/PI3K and TOR (Target Of mTOR(definition)-inhibiting drug studied for extending healthspan and lifespan." style="text-decoration:underline dotted; text-underline-offset:2px; cursor:help;">Rapamycin(definition)) pathways. In accordance with that, genetic suppression of these routes results in longevity in worms and flies. Recent findings showed that all these effects are dependent on autophagy, the lysosome-mediated degradation of the cytoplasm. I will present our results on the effect of autophagy manipulation on longevity in Drosophila. Keywords: comparative endocrinology Conference: 25th Conference of the European Comparative Endocrinologists, Pécs, Hungary, 31 Aug - 4 Sep, 2010. Presentation Type: Conference Presentation Topic: Comparative endocrinology Citation: Juhász G, Érdi B, Sass M and Neufeld TP (2010). Regulation of lifespan through the Insulin/PI3K/TOR/autophagy pathway. Front. Endocrinol. Conference Abstract: 25th Conference of the European Comparative Endocrinologists. doi: 10.3389/conf.fendo.2010.01.00003 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 25 Aug 2010; Published Online: 29 Aug 2010. * Correspondence: Dr. Gábor Juhász, Eotvos Lorand University, Department of Anatomy, Cell and Developmental Biology, Budapest, Hungary, [email protected] Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Gábor Juhász Balazs Érdi Miklós Sass Thomas P Neufeld Google Gábor Juhász Balazs Érdi Miklós Sass Thomas P Neufeld Google Scholar Gábor Juhász Balazs Érdi Miklós Sass Thomas P Neufeld PubMed Gábor Juhász Balazs Érdi Miklós Sass Thomas P Neufeld Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.