Combatting the impact of aging on recovery from brain injury

Event Abstract Back to Event Combatting the impact of aging on recovery from brain injury Jolien M. Van Houcke1, Eve Seuntjens2 and Lut Arckens1* 1 KU Leuven, Biology, Belgium 2 KU Leuven, Biology, Belgium Traumatic brain injury (TBI) has a large impact on victim and society and will be one of the main causes of death and disability by 2020, yet effective treatment is unavailable. Its increased prevalence in elderly, with a worsened outcome, urges the use of a model in which the cellular and molecular components of neuronal regeneration can be unravelled in an aging context. We use the extraordinary short-lived African Turquoise killifish (N. furzeri), a rapid aging model and thus ideal to unravel the impact of aging on successful regeneration upon injury. By introducing a stab-wound in the telencephalon of young and aged fish, we provide a fast and robust TBI model to elucidate the underlying cellular and molecular processes of de novo neurogenesis, differentiation, outgrowth and synaptogenesis, and how they are affected with age. We will explore the contribution of radial glia and peculiar, abundant highly-proliferative neuronal progenitor cells (hpNPCs) in neuroregeneration of the telencephalon. More importantly, the molecular players that differentiate the injury repair between young and aged fish will be identified via a functional proteomics approach targeted towards identifying drugable plasma membrane proteins, and validated via pharmacological interventions or genetic manipulation in our optimized TBI model. Keywords: Traumatic brain injury (TBI), Aging, Nothobranchius furzeri, Regeneration, Neurogenesis Conference: 12th National Congress of the Belgian Society for Neuroscience, Gent, Belgium, 22 May - 22 May, 2017. Presentation Type: Poster Presentation Topic: Disorders of the Nervous System Citation: Van Houcke JM, Seuntjens E and Arckens L (2019). Combatting the impact of aging on recovery from brain injury. Front. Neurosci. Conference Abstract: 12th National Congress of the Belgian Society for Neuroscience. doi: 10.3389/conf.fnins.2017.94.00078 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 19 Apr 2017; Published Online: 25 Jan 2019. * Correspondence: Prof. Lut Arckens, KU Leuven, Biology, Leuven, 3000, Belgium, [email protected] Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Jolien M Van Houcke Eve Seuntjens Lut Arckens Google Jolien M Van Houcke Eve Seuntjens Lut Arckens Google Scholar Jolien M Van Houcke Eve Seuntjens Lut Arckens PubMed Jolien M Van Houcke Eve Seuntjens Lut Arckens Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.