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NIA Interventions Testing Program: Investigating Putative Aging Intervention Agents in a Genetically Heterogeneous Mouse Model

Nancy L. Nadon, Randy Strong, Richard A. Miller, David E. Harrison

EBioMedicine · 2016 · ▲ 149 citations

Deregulated nutrient-sensing Caloric restriction Rapamycin / mTOR inhibition Mouse

Abstract

The Interventions Testing Program (ITP) was established by the National Institute on Aging (NIA) to investigate the potential of dietary interventions to promote healthy aging (https://www.nia.nih.gov/research/dab/interventions-testing-program-itp). The ITP uses a four-way cross genetically heterogeneous mouse model (UM-HET3) to reduce the impact of strain-specific characteristics on outcomes (Nadon et al., 2008). Lifespan tests are done in parallel, using the same protocol, at three independent sites to increase robustness of the findings.

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Provenance

Source: OpenAlex
DOI: 10.1016/j.ebiom.2016.11.038
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Fetched: 2026-08-04 MST

Cite this

APA

Nadon, N.L., Strong, R., Miller, R.A., & Harrison, D.E. (2016). NIA Interventions Testing Program: Investigating Putative Aging Intervention Agents in a Genetically Heterogeneous Mouse Model. <em>EBioMedicine</em>. https://doi.org/10.1016/j.ebiom.2016.11.038

Vancouver

Nadon NL, Strong R, Miller RA, Harrison DE. NIA Interventions Testing Program: Investigating Putative Aging Intervention Agents in a Genetically Heterogeneous Mouse Model. EBioMedicine. 2016. doi:10.1016/j.ebiom.2016.11.038.

BibTeX

@article{nancy2016NIAInt, title = {NIA Interventions Testing Program: Investigating Putative Aging Intervention Agents in a Genetically Heterogeneous Mouse Model}, author = {Nancy L. Nadon and Randy Strong and Richard A. Miller and David E. Harrison}, journal = {EBioMedicine}, year = {2016}, doi = {10.1016/j.ebiom.2016.11.038}, }