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Molecular mechanisms of exceptional lifespan increase of Drosophila melanogaster with different genotypes after combinations of pro-longevity interventions

Mikhail Shaposhnikov, Zulfiya G. Guvatova, Nadezhda Zemskaya, Liubov Koval, Eugenia V. Schegoleva, Anastasia A. Gorbunova, Denis A. Golubev, N. Pakshina, Natalia S. Ulyasheva, Ilya Solovev, Мargarita А. Bobrovskikh, Н. Е. Грунтенко, Petr N. Menshanov, George S. Krasnov, Anna V. Kudryavseva

Communications Biology · 2022 · ▲ 26 citations

Epigenetic alterations Deregulated nutrient-sensing Disabled macroautophagy Caloric restriction Rapamycin / mTOR inhibition Drosophila

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Abstract

Abstract Aging is one of the global challenges of our time. The search for new anti-aging interventions is also an issue of great actuality. We report on the success of Drosophila melanogaster lifespan extension under the combined influence of dietary restriction, co-administration of berberine, fucoxanthin, and mTOR-inhibiting drug studied for extending healthspan and lifespan." style="text-decoration:underline dotted; text-underline-offset:2px; cursor:help;">rapamycin, photodeprivation, and low-temperature conditions up to 185 days in w 1118 strain and up to 213 days in long-lived E(z)/w mutants. The trade-off was found between longevity and locomotion. The transcriptome analysis showed an impact of epigenetic alterations, lipid metabolism, cellular respiration, nutrient sensing, immune response, and autophagy in the registered effect.

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Provenance

Source: OpenAlex
DOI: 10.1038/s42003-022-03524-4
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Fetched: 2026-06-30 MST

Cite this

APA

Shaposhnikov, M., Guvatova, Z.G., Zemskaya, N., Koval, L., Schegoleva, E.V., Gorbunova, A.A., Golubev, D.A., Pakshina, N., Ulyasheva, N.S., Solovev, I., Bobrovskikh, �.�., Грунтенко, �.�., Menshanov, P.N., Krasnov, G.S., Kudryavseva, A.V., & Moskalev, A. (2022). Molecular mechanisms of exceptional lifespan increase of Drosophila melanogaster with different genotypes after combinations of pro-longevity interventions. <em>Communications Biology</em>. https://doi.org/10.1038/s42003-022-03524-4

Vancouver

Shaposhnikov M, Guvatova ZG, Zemskaya N, Koval L, Schegoleva EV, Gorbunova AA, et al. Molecular mechanisms of exceptional lifespan increase of Drosophila melanogaster with different genotypes after combinations of pro-longevity interventions. Communications Biology. 2022. doi:10.1038/s42003-022-03524-4.

BibTeX

@article{mikhail2022Molecu, title = {Molecular mechanisms of exceptional lifespan increase of Drosophila melanogaster with different genotypes after combinations of pro-longevity interventions}, author = {Mikhail Shaposhnikov and Zulfiya G. Guvatova and Nadezhda Zemskaya and Liubov Koval and Eugenia V. Schegoleva and Anastasia A. Gorbunova and Denis A. Golubev and N. Pakshina and Natalia S. Ulyasheva and Ilya Solovev and Мargarita А. Bobrovskikh and Н. Е. Грунтенко and Petr N. Menshanov and George S. Krasnov and Anna V. Kudryavseva and Alexey Moskalev}, journal = {Communications Biology}, year = {2022}, doi = {10.1038/s42003-022-03524-4}, }