Long noncoding RNAs (lncRNAs) and the molecular hallmarks of aging

During aging, progressive deleterious changes increase the risk of disease and death. Prominent molecular telomere(definition) attrition, cellular senescence(definition))." style="text-decoration:underline dotted; text-underline-offset:2px; cursor:help;">hallmarks of aging(definition) are genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis(definition), cellular senescence, stem cell exhaustion, and altered intercellular communication. Long noncoding RNAs (lncRNAs) play important roles in a wide range of biological processes, including age-related diseases like cancer, cardiovascular pathologies, and neurodegenerative disorders. Evidence is emerging that lncRNAs influence the molecular processes that underlie age-associated phenotypes. Here, we review our current understanding of lncRNAs that control the development of aging traits.