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Extension of the Life Span by Acarbose: Is It Mediated by the Gut Microbiota?

Baiyun Wu, Jiai Yan, Ju Yang, Yanping Xia, Dan Li, Feng Zhang, Hong Cao

Aging and Disease · 2022 · ▲ 15 citations

Telomere attrition Dysbiosis Mitochondrial dysfunction Cellular senescence Mouse Review

Abstract

Acarbose can extend the life span of mice through a process involving the gut microbiota. Several factors affect the life span, including mitochondrial function, cellular senescence, telomere length, immune function, and expression of longevity-related genes. In this review, the effects of acarbose-regulated gut microbiota on the life span-influencing factors have been discussed. In addition, a novel theoretical basis for improving our understanding of the mechanisms by which acarbose extends the life span of mice has been suggested.

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Provenance

Source: OpenAlex
DOI: 10.14336/ad.2022.0117
Canonical: link ↗
Fetched: 2026-06-29 MST

Cite this

APA

Wu, B., Yan, J., Yang, J., Xia, Y., Li, D., Zhang, F., & Cao, H. (2022). Extension of the Life Span by Acarbose: Is It Mediated by the Gut Microbiota?. <em>Aging and Disease</em>. https://doi.org/10.14336/ad.2022.0117

Vancouver

Wu B, Yan J, Yang J, Xia Y, Li D, Zhang F, et al. Extension of the Life Span by Acarbose: Is It Mediated by the Gut Microbiota?. Aging and Disease. 2022. doi:10.14336/ad.2022.0117.

BibTeX

@article{baiyun2022Extens, title = {Extension of the Life Span by Acarbose: Is It Mediated by the Gut Microbiota?}, author = {Baiyun Wu and Jiai Yan and Ju Yang and Yanping Xia and Dan Li and Feng Zhang and Hong Cao}, journal = {Aging and Disease}, year = {2022}, doi = {10.14336/ad.2022.0117}, }