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Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy

Dominic Denk, Valentina Petrocelli, Claire Conche, Moritz Drachsler, Paul K. Ziegler, Angela Braun, Alena Kress, Adele M. Nicolas, Kathleen Mohs, Christoph Becker, Markus F. Neurath, Henner F. Farin, Christian J. Buchholz, Pénélope A. Andreux, Chris Rinsch

Immunity · 2022 · ▲ 135 citations

Disabled macroautophagy Stem-cell exhaustion

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Abstract

Anti-tumor immunity is limited by reduced T cell persistence and antigen presentation. Denk et al. show that Urolithin A, a natural metabolite of pomegranate extract, enhances antigen presentation in cancer and promotes mitophagy in CD8 + T cells, resulting in generation regenerative stem cell-like memory (T SCM ) cells with enhanced antitumor properties.

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Provenance

Source: OpenAlex
DOI: 10.1016/j.immuni.2022.09.014
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Fetched: 2026-06-11 MST

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APA

Denk, D., Petrocelli, V., Conche, C., Drachsler, M., Ziegler, P.K., Braun, A., Kress, A., Nicolas, A.M., Mohs, K., Becker, C., Neurath, M.F., Farin, H.F., Buchholz, C.J., Andreux, P.A., Rinsch, C., & Greten, F.R. (2022). Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy. <em>Immunity</em>. https://doi.org/10.1016/j.immuni.2022.09.014

Vancouver

Denk D, Petrocelli V, Conche C, Drachsler M, Ziegler PK, Braun A, et al. Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy. Immunity. 2022. doi:10.1016/j.immuni.2022.09.014.

BibTeX

@article{dominic2022Expans, title = {Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy}, author = {Dominic Denk and Valentina Petrocelli and Claire Conche and Moritz Drachsler and Paul K. Ziegler and Angela Braun and Alena Kress and Adele M. Nicolas and Kathleen Mohs and Christoph Becker and Markus F. Neurath and Henner F. Farin and Christian J. Buchholz and Pénélope A. Andreux and Chris Rinsch and Florian R. Greten}, journal = {Immunity}, year = {2022}, doi = {10.1016/j.immuni.2022.09.014}, }