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AMPK-PDZD8-GLS1 axis mediates calorie restriction-induced lifespan extension

Mengqi Li, Yu Wang, Xiaoyan Wei, Wei-Feng Cai, Yan‐Hui Liu, Jianfeng Wu, Yan Chen, Jinye Xiong, Lifeng Cui, Mingxia Zhu, Cixiong Zhang, Liyun Lin, Yong Yu, Hai‐long Piao, Sheng‐Cai Lin

Cell Research · 2024 · ▲ 14 citations

Deregulated nutrient-sensing Caloric restriction Yeast C. elegans Non-human primate Mouse

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Abstract

Calorie restriction (CR) that chronically reduces average daily caloric intake without causing malnutrition has been recognized as a non-pharmacological dietary behavior for improving health. 1 The benefits of CR have been observed in various species, including yeast, nematodes, mice, and primates, showing a general link between reduced food intake and longevity. 2 During CR, organisms undergo metabolic changes or adaptations, such as a shift from primarily consuming glucose to fatty acid and amino acid catabolism. 3 , 4 However, the mechanism behind these adaptations and their relationship to the lifespan extension mediated by CR remains largely unknown.

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Provenance

Source: OpenAlex
DOI: 10.1038/s41422-024-01021-3
Canonical: link ↗
Fetched: 2026-06-15 MST

Cite this

APA

Li, M., Wang, Y., Wei, X., Cai, W., Liu, Y., Wu, J., Chen, Y., Xiong, J., Cui, L., Zhu, M., Zhang, C., Lin, L., Yu, Y., Piao, H., Lin, S., & Zhang, C. (2024). AMPK-PDZD8-GLS1 axis mediates calorie restriction-induced lifespan extension. <em>Cell Research</em>. https://doi.org/10.1038/s41422-024-01021-3

Vancouver

Li M, Wang Y, Wei X, Cai W, Liu Y, Wu J, et al. AMPK-PDZD8-GLS1 axis mediates calorie restriction-induced lifespan extension. Cell Research. 2024. doi:10.1038/s41422-024-01021-3.

BibTeX

@article{mengqi2024AMPKPD, title = {AMPK-PDZD8-GLS1 axis mediates calorie restriction-induced lifespan extension}, author = {Mengqi Li and Yu Wang and Xiaoyan Wei and Wei-Feng Cai and Yan‐Hui Liu and Jianfeng Wu and Yan Chen and Jinye Xiong and Lifeng Cui and Mingxia Zhu and Cixiong Zhang and Liyun Lin and Yong Yu and Hai‐long Piao and Sheng‐Cai Lin and Chen‐Song Zhang}, journal = {Cell Research}, year = {2024}, doi = {10.1038/s41422-024-01021-3}, }