Spermidine

Induction of autophagy by spermidine promotes longevity

Age-Associated Mitochondrial Dysfunction Accelerates Atherogenesis

Rationale: Aging is one of the strongest risk factors for atherosclerosis. Yet whether aging increases the risk of atherosclerosis independently of chronic hyperlipidemia is not known. Objective: To determine if vascular aging before the in...

S‐adenosylmethionine: A metabolite critical to the regulation of autophagy

Autophagy is a mechanism that enables cells to maintain cellular homeostasis by removing damaged materials and mobilizing energy reserves in conditions of starvation. Although nutrient availability strongly impacts the process of autophagy,...

Autophagy in ageing and ageing-associated diseases

Autophagy is a cell self-digestion process via lysosomes that clears "cellular waste", including aberrantly modified proteins or protein aggregates and damaged organelles. Therefore, autophagy is considered a protein and organelle quality c...

Are mitophagy enhancers therapeutic targets for Alzheimer’s disease?

Healthy mitochondria are essential for functional bioenergetics, calcium signaling, and balanced redox homeostasis. Dysfunctional mitochondria are a central aspect of aging and neurodegenerative diseases such as Alzheimer’s disease (AD). Th...

Autophagy in age-related liver disease

Aging profoundly impacts liver physiology by disrupting autophagy, a lysosome-dependent degradation pathway essential for maintaining cellular homeostasis. Autophagy declines with aging due to reduced expression of core autophagy-related (A...

Insights into the therapeutic strategies for aging and aging-associated diseases

Aging is a complex biological process characterized by progressive functional decline, driving the incidence of age-related diseases such as neurodegeneration, metabolic disorders, and cardiovascular diseases. Therapeutic strategies targeti...

Polyamine metabolism as a regulator of cellular and organismal aging.

Polyamines - putrescine, spermidine, and spermine - are ubiquitous cationic molecules that are essential for cellular proliferation and homeostasis. Their intracellular concentrations decline with age, contributing to physiological and cogn...

Dietary pyrroloquinoline quinone and spermidine in healthy longevity: targeting the hallmarks of aging

Background: Aging is a multifaceted biological process driven by interconnected cellular and molecular hallmarks. As geroscience increasingly prioritizes healthspan over lifespan, nutritional interventions targeting multiple aging mechanism...

A Phase 1b, Multi-cohort Clinical Trial Assessing Safety and Feasibility of Exercise and Spermidine Administered in Conjunction With Lamivudine (RTi) or Rapamycin (mTORi) to Assess Impact on Dynamic Changes of Inflammation and Aging

This is a study assessing the feasibility of performing an anti-aging intervention which is a combination of an exercise regimen, spermidine supplementation, and either rapamycin or lamivudine.