Longevity intervention
Spermidine
- Works
- 315
- Most cited
- 1,694
Most-cited works
Induction of autophagy by spermidine promotes longevity
Discover how the natural polyamine spermidine induces autophagy, extending lifespan in yeast, flies, worms, and mice. Published in Nature Cell Biology (2009).
Cardioprotection and lifespan extension by the natural polyamine spermidine
This study in Nature Medicine 2016 examines the effects of the natural polyamine spermidine on cardiac function and organismal lifespan.
Remaining Mysteries of Molecular Biology: The Role of Polyamines in the Cell
The polyamines (PAs) spermidine, spermine, putrescine and cadaverine are an essential class of metabolites found throughout all kingdoms of life. In this comprehensive review, we discuss their metabolism, their various intracellular functio...
Polyamines in aging and disease
Polyamines are polycations that interact with negatively charged molecules such as DNA, RNA and proteins. They play multiple roles in cell growth, survival and proliferation. Changes in polyamine levels have been associated with aging and d...
Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome
Autophagy protects organelles, cells, and organisms against several stress conditions. Induction of autophagy by resveratrol requires the nicotinamide adenine dinucleotide-dependent deacetylase sirtuin 1 (SIRT1). In this paper, we show that...
Spermidine induces autophagy by inhibiting the acetyltransferase EP300
This 2014 study published in Cell Death and Differentiation investigates the role of spermidine in inducing autophagy through the inhibition of EP300.
Polyamines Control eIF5A Hypusination, TFEB Translation, and Autophagy to Reverse B Cell Senescence
Failure to make adaptive immune responses is a hallmark of aging. Reduced B cell function leads to poor vaccination efficacy and a high prevalence of infections in the elderly. Here we show that reduced autophagy is a central molecular mech...
Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice
Prevention of quality of life (QOL) deterioration is associated with the inhibition of geriatric diseases and the regulation of brain function. However, no substance is known that prevents the aging of both body and brain. It is known that...
Polyamines in Food
The polyamines spermine, spermidine and putrescine are involved in various biological processes, notably in cell proliferation and differentiation, and also have antioxidant properties. Dietary polyamines have important implications in huma...
The crucial impact of lysosomes in aging and longevity
Lysosomes are the main catabolic organelles of a cell and play a pivotal role in a plethora of cellular processes, including responses to nutrient availability and composition, stress resistance, programmed cell death, plasma membrane repai...
Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon
Intestinal microbiota-derived metabolites have biological importance for the host. Polyamines, such as putrescine and spermidine, are produced by the intestinal microbiota and regulate multiple biological processes. Increased colonic lumina...
Higher spermidine intake is linked to lower mortality: a prospective population-based study
This prospective population-based study in the American Journal of Clinical Nutrition examines the association between spermidine intake and mortality.